Postdoctoral Research Fellow

University of Exeter - University of Exeter Medical School

This MRC-funded post is available 1 January 2018 for three years.

The University of Exeter is a Russell Group university that combines world-class research with very high levels of student satisfaction. Exeter has over 21,000 students from more than 130 different countries and is in the top 1% of universities in the world with 98% of its research rated as being of international quality. Our research focuses on some of the most fundamental issues facing humankind today.

We are seeking a highly motivated Postdoctoral Research Fellow to join the Complex Disease (Epi)genomics Group at the University of Exeter Medical School. The successful applicant will work on an interdisciplinary project that aims to characterise regulatory genomic variation in schizophrenia brain. We are a dynamic, interdisciplinary team including molecular biologists, geneticists, mathematicians and bioinformaticians.

Building on our previous work exploring epigenomic variation in schizophrenia this project involves profiling genomic signatures (DNA modifications, histone modifications, gene expression, alternative splicing) in purified neuronal nuclei isolated from a unique collection of post-mortem brain samples. Given the evidence for a neurodevelopmental component to the aetiology of schizophrenia, we will also annotate patterns of gene regulation across development of the human cortex, enabling us to explore the hypothesis that disease-associated loci are dynamically regulated during this critical period.

You will play a leading role in this integrated-genomics project, exploring the dynamic regulation of gene function during human brain development and its relevance to the aetiology of schizophrenia.

About you

We are particularly interested in applications from ambitious postdoctoral scientists with expertise in any of the following: molecular biology, epigenomics (DNA and histone modification analysis), genomic sequencing (ChIP-seq and Pacific Biosciences Iso-seq), applied mathematics, computational biology, or bioinformatics. Applicants may be either laboratory-based or informatics-focused; please state your preferred position in the application.

Applicants must possess a relevant PhD or equivalent qualification/experience in a related field of study. The successful applicant will be a nationally recognised authority in their area of expertise and possess sufficient specialist knowledge in the discipline to develop research programmes and methodologies. The successful applicant will also be able to work collaboratively, supervise the work of others and act as team leader as required.

What we can offer you

  •  Freedom (and the support) to pursue your intellectual interests and to work creatively across disciplines to produce internationally exciting research
  • Support teams that understand the University wide research and teaching goals and partner with our academics accordingly
  • Our Exeter Academic initiative supporting high performing academics to achieve their potential and develop their career

To view the Job Description and Person Specification please click here.

For further information please contact Professor Jonathan Mill j.mill@exeter.ac.uk

The College is proud to have a Silver Athena SWAN award in recognition of our commitment and impact to providing equality of opportunity and advancing the representation of women in STEM/M subjects. Our Inspiring Stories tell you more about how we support our staff, including through a mentoring programme to help our staff learn from the professional and life experience of colleagues and explore opportunities and actions for career progression.

The University of Exeter is an equal opportunity employer. We are officially recognised as a Disability Confident employer and an Athena Swan accredited institution. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce.

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