Crick-Cancer Research UK and Crick Doctoral Fellowships for Clinicians 2018

The Francis Crick Institute

Applications are invited for Crick–Cancer Research UK and Crick doctoral fellowships for clinicians at the Francis Crick Institute (the Crick). These fellowships provide an opportunity for outstanding clinicians to perform innovative biomedical discovery research for three years while following the Crick’s clinical PhD programme.

The Crick carries out multidisciplinary research dedicated to unravelling the scientific mechanisms of living organisms, helping us to understand why disease develops and find new ways to prevent, diagnose and treat illnesses. One of the Crick’s aims is to provide an environment to advance the understanding of cancer at the most fundamental level and to speed application of this knowledge for therapeutic and diagnostic patient benefit.

Fellows will be based at the Crick, supported by teams comprising a Crick research group leader, at least one supervisor from one of Crick’s five clinical PhD programme partners (Barts Cancer Institute/Queen Mary University of London, Imperial College London, The Institute of Cancer Research, King’s College London and UCL) and at least one clinician.

We are interested in recruiting fellows to the following projects and supervisory teams:

Crick-Cancer Research UK projects

  • Cancer outcome in standard and immune checkpoint blockade therapies. Dinis Calado (Crick), Jude Fitzgibbon (Barts Cancer Institute/QMUL) and Peter Johnson (University of Southampton)
  • Investigation of the mechanisms by which RAS mutant lung cancer evades the immune system. Julian Downward (Crick), Alan Melcher (ICR) and Sanjay Popat (ICR, Royal Marsden)
  • Genomic assessment of DNA damage in skin cancers. Nicholas Luscombe (Crick), Fiona Watt and Magnus Lynch (King’s College London)
  • Identification of novel targets to inhibit autophagy in advanced pancreatic cancer. Sharon Tooze (Crick), Christopher Heeschen (Barts Cancer Institute, QMUL) and David Propper (Barts and The London NHS Trust)
  • The serum response factor (SRF) network in cancer development. Richard Treisman (Crick) and Daniel Hochhauser (UCL)
  • Metabolic stratification of tumours for chemotherapy. Mariia Yuneva (Crick), Robert Stein and Gyorgy Szabadkai (UCL)

Crick projects

  • Mechanisms and therapeutic exploitation of alternative lengthening of telomeres (ALT) acquisition in cancers. Simon Boulton (Crick) and Daniel Hochhauser (UCL)
  • Regulation of IL-10 versus pro-inflammatory cytokines in human macrophages and dendritic cells. Anne O’Garra (Crick) and Catherine Hawrylowicz (King’s College London)
  • Environmental influences on intestinal homeostasis and inflammation. Brigitta Stockinger (Crick) and Graham Lord (King’s College London)
  • The role of actin-related protein (Arp) 2/3 complex isoforms in muscle development, homeostasis and early-onset neuromuscular disorders. Michael Way (Crick) and Heinz Jungbluth (King’s College London) 

We are looking for talented and motivated clinicians from all medical and surgical specialities who are passionate about research, have a strong academic track record and hold full GMC registration or equivalent.

These are full-time research positions with limited participation in clinical activities. They are fully funded for three years, and PhD registration will be with the appropriate programme partner institution. Successful candidates will receive a salary commensurate with their current experience, paid on the clinical academic scale.

For information on positions, eligibility and how to apply, visit:

Application deadline: Tuesday 14 November 2017
Interviews: Tuesday 6 February 2018
Start date: September 2018

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