Postdoctoral Scientist in Prostate Oncobiology

The University of Manchester

Duration: 3 year position

About the role:

We are looking for a highly-motivated Postdoctoral Scientist to join Dr Baena’s Prostate Oncobiology group. The work of Dr Baena’s group is focused on dissecting the role of prostate progenitor subpopulations on aggressive prostate cancer initiation to identify novel therapeutic targets.

A major challenge in prostate cancer management is to distinguish indolent from aggressive prostate cancer as a consequence of genetic and cellular heterogeneity. Our current studies suggest that this cell-of-origin model may have implications for the development of castrate resistant disease. The successful applicant will work on a project delineating castration-resistant cancer initiation to develop novel biomarkers and therapies. A particular focus of this project is the understanding of the transcriptional program of the newly identified castration-resistant tumour initiating cells, and to functionally characterize how these cells contribute to disease progression. 

About you:

You must hold a PhD in a relevant related subject and have research laboratory experience. You will be well-grounded in basic cellular and molecular biology and have experience of working with in vivo cancer models. You will also have significant experience of cell culture, particularly in vitro 3D culture systems and handling primary cells. Profound experience in FACS analyses and lineage tracing work is also essential for this position.

This is an exciting opportunity for you to be involved in developing and driving the project as well as writing up work for presentation and publication.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned Manchester Cancer Research Centre (MCRC) in South Manchester and life sciences campus at Alderley Park in Cheshire England. We are adjacent to our partner hospital, The Christie NHS Foundation Trust in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

The CRUK Manchester Institute is a key part of the Belfast-Manchester Movember Centre of Excellence for Prostate Cancer. As well as bringing together expert researchers and clinicians, the Movember Centres of Excellence will also provide a world-class training ground for the scientists of the future, building a legacy of top prostate cancer researchers in the UK, as well as establishing international collaborations for the brightest minds to tackle the most important questions in prostate cancer research – now and into the future.

How to apply?

To apply for this position please visit our website: www.cruk.manchester.ac.uk

For any informal enquiries about this post, please contact Dr. Esther Baena, via email: esther.baena@cruk.manchester.ac.uk

Closing date: 9 November 2017.

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