Postdoctoral Research Associate in Imaging Chromatin and Gene Expression

University of Oxford - Department of Biochemistry

This is a re-advertisement and previous applicants should not re-apply.

We are seeking to appoint a postdoctoral research associate to join Professor Rob Klose’s research group ( which studies how chromatin based processes regulate gene expression. The Klose group have recently made a series of important discoveries examining how polycomb repressive systems function at CpG island gene regulatory elements. Now, in collaboration with the Schermelleh group (, we aim to discover how polycomb systems regulate transcription in vivo, through applying single-cell imaging approaches. To achieve this, a postdoctoral associate will be recruited to pioneer single-cell analysis of the polycomb system and understand how it engages with chromatin and regulates gene expression. 

Applicants should possess, or be in the process of completing, a PhD in a relevant subject. You will have a strong background exploiting both fixed and live-cell imaging approaches to address important biological questions, ideally in mammalian systems. You should have a keen interest in chromatin biology and gene expression, and have demonstrated a talent for making important discoveries as evident from publication. Furthermore, you would ideally have experience in; mammalian cell culture, single molecule RNA-FISH, live-cell imaging of fluorescently labelled proteins, live-cell imaging of transcription using MS2 based or related systems, single molecule tracking, advanced image analysis, and super-resolution microscopy, although training in certain aspects of this work could be provided. Experience applying mathematical modelling to the understanding of stochastic processes like gene transcription would also be beneficial. You must work independently, formulate research idea  s, and drive research to completion and publication. The collaborative nature of the Klose group requires excellent organizational, communication, and writing skills.

This full-time fixed-term post is funded by the ERC for up to 3 years in the first instance.

Further particulars, including details of how to apply, can be obtained from the document below.

The closing date for applications is 12.00 noon on Friday 19 January 2018, with interviews for shortlisted candidates to be held as soon as possible thereafter.

Please note that the University of Oxford's retirement policy has changed. With effect from 1 October 2017, all employees at Grade 8 and above have a retirement age of the 30 September before the 69th birthday. All employees at Grades 1-7 do not have a set retirement age. Further details are available here:

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