Senior Laboratory Research Scientist – Quantitative Cell Biology

The Francis Crick Institute

Contract: Fixed-term (4 years), Full time

Short Introduction/Summary

We are looking for a highly motivated Senior Laboratory Scientist to join the quantitative cell biology laboratory headed by Dr Silvia Santos. The lab is a new addition to The Francis Crick Institute in London and focuses on understanding control principles in cell decision-making. Current areas of research include understanding control of cell division and differentiation, using human embryonic stem cells as a model system. There is a strong focus on single cell analysis and live cell imaging approaches. The team is currently composed of three PhD students and two post-doctoral fellows. For more information please see quantcellbio.wordpress.com

The successful post holder is expected to drive his/her own research, help with lab management and training and support on-going research projects. The ideal candidate is likely to be an energetic, focused and productive individual with a desire to work on interesting biological problems in a collegial and collaborative work environment.  Excellent time management and organisation skills are essential.

Project Scope/ Description

The decision to divide is a fundamental cellular decision and the conserved networks that trigger cell division adapt and remodel in a variety of biological contexts including developmental transitions and malignancy. We have been exploring spatio-temporal control of cell division in mammalian cells and remodelling of cell cycle networks during developmental transitions, using embryonic stem cells as a model system.

Embryonic stem cells have the propensity to differentiate into the three germ layers. The switch between pluripotency and differentiation in these cells has been our paradigm of choice to understand how protein and gene networks decode cellular signals and thereby encode irreversible commitment to different cell fates.

The molecular basis of these decisions is of fundamental biological importance and have significant clinical applications.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 19 December 2017 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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London