2 PhD Studentships: Natural product pharmacology

University of Hull

To celebrate the University's research successes, the University of Hull is offering a full-time UK/EU PhD Scholarship or International Fees Bursary for candidates applying for each of the following projects.

Closing date: - Thursday 8th February 2018

Studentships will start on 17th September 2018

For further information regarding this project, please contact Dr Huw Jones (huw.jones@hull.ac.uk, http://beta.www.hull.ac.uk/Faculties/staff-profiles/Huw-Jones.aspx).

Summary of Cluster

The natural product pharmacology cluster is comprised of researchers from the School of Mathematics and Physical Sciences (biochemistry and chemistry) and School of Life Sciences (biomedical sciences and sport, health and exercise sciences). The cluster research focus aims to understand the drug-like properties of natural products (plant chemicals, etc.) in diseases associated with ageing, such as skeletal muscle decline. Such diseases are difficult to treat (with severely limited therapeutic options), yet result in a substantial health and social care burden. The cluster has a strong focus on the modulation of reactive oxygen species and mitochondrial function in diseases of ageing, and the production of circulating metabolites of natural products. Two University of Hull funded PhD studentships investigating these areas are detailed below.

Summary of PhD Project 1

Natural products (such as dietary polyphenols) undergo substantial metabolic processing in humans, resulting the production of a wide variety of metabolic derivatives in the blood. Cell-based assessments of the drug-like effects of natural products may well be limited in the reflection of in vivo systems, due to a lack of availability of these metabolic derivatives for use in testing. This project will investigate the adaptation of microfluidic technologies to the synthesis of these metabolites. As part of this approach the successful candidate will gain experience in the construction and use of microfluidic reactors, undertake product characterisation using analytical chemistry approaches (e.g. LC-MS, NMR), and experience enzyme production methods. Due to the analytical nature of this project, applicants with understanding or experience of analytical chemistry techniques, synthesis, and drug metabolism processes are sought. This project will be supervised by Dr Huw Jones, Dr Kevin Welham, and Prof Nicole Pamme. For further information regarding this project please contact Dr Huw Jones (huw.jones@hull.ac.uk, http://beta.www.hull.ac.uk/Faculties/staff-profiles/Huw-Jones.aspx).

Summary of PhD Project 2

The loss of skeletal muscle function with ageing results in a progressive increase in frailty and a substantial reduction in quality of life. There are currently no effective therapies for skeletal muscle decline. This project will use cell culture models of muscle ageing to screen a range of natural products for bioactive effects upon ageing phenotypes. Specifically it will focus upon changes in mitochondrial function and reactive oxygen species signalling pathways, processes that have been implicated in the pathogenesis of skeletal muscle decline. Compounds that demonstrate bioactivities in vitro will also be translated into human subjects.  Within this approach the successful candidate will gain experience of a range of molecular biology and biochemical techniques, in addition to the application of analytical chemistry approaches to biological samples (e.g. LC-MS). Thus applicants for this project should have understanding or experience of cell culture and cell metabolism and biochemistry. Applicants with a medical degree are encouraged to apply for this project. This project will be supervised by Dr Huw Jones, Dr Mark Fogarty and Dr Frank Voncken. For further information regarding this project please contact Dr Huw Jones (huw.jones@hull.ac.uk, http://beta.www.hull.ac.uk/Faculties/staff-profiles/Huw-Jones.aspx).

Applicants should have at least a 2.1 undergraduate degree in chemistry, biochemistry, toxicology, or related disciplines for project 1, and medicine, biochemistry, biomedical sciences, molecular cell biology, or related disciplines for project 2, together with relevant research or clinical experience. It is anticipated that the successful applicant will have a 1st class undergraduate degree or a Masters level qualification.

To apply for these Scholarships please click on the Apply button below.                                          

http://www2.hull.ac.uk/student/admissions/postgraduate/phd-scholarships.aspx

Full-time UK/EU PhD Scholarships will include fees at the ‘home/EU' student rate and maintenance (£14,553 in 2017/18) for three years, depending on satisfactory progress.

Full-time International Fee PhD Studentships will include full fees at the International student rate for three years, dependent on satisfactory progress.

PhD students at the University of Hull follow modules for research and transferable skills development and gain a Masters level Certificate, or Diploma, in Research Training, in addition to their research degree.

Successful applicants will be informed of the award as soon as possible and by 2nd April 2018 at the latest.

Share this PhD
     
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

PhD

Location(s):

Northern England