PhD Research Studentship: Lipidomic Analysis of Biological Samples: Identification of Bioactive Lipids Associated with Osteoarthritic Pain

University of Nottingham - Clinical Neuroscience

Osteoarthritis (OA) is a major clinical problem, and chronic pain is one of the dominant presenting symptoms. There are major gaps in our understanding of the mechanisms of OA pain. LC-MS/MS is a highly sensitive method for the analysis of biological samples, which we have used to quantify levels of bioactive lipids in plasma samples from OA sufferers. The aim of this studentship is to build upon this work to identify, and quantify, levels of bioactive lipids in plasma samples from OA sufferers and to perform statistical and pathway analysis with existing clinical data from these subjects (including pain scores). Some additional cell biology methods will be used to address specific hypotheses leading from the studies.

This project will involve the use of mass spectrometry, cell biology techniques and statistical and pathway analysis thereby providing comprehensive skills and training to students embarking on a career in biomedical research. This project will be supervised by Professors Victoria Chapman and David Barrett and Dr Ana Valdes and will be embedded within the Nottingham Biomedical Research Centre.

This study is being supported by the newly established NIHR Nottingham BRC and will benefit from collaborations within the BRC and the Arthritis Research UK Pain Centre.

Applicants should have, or will expect to attain at least a 2:1 degree classification in biochemistry, pharmacology, neuroscience or physiology (or a related discipline).

The successful student will be registered for a PhD; the studentship is available from September for a period of three years and provides a postgraduate stipend of £14,624 in year 1 with increments in line with Research Council Rates. This studentship is available to UK/EU citizens. 

The University of Nottingham is the top 1% of global universities and is ranked eighth in the UK on a measure of ‘research power’, with more than 80% of research rated as world-leading or internationally excellent. The University of Nottingham also offers a world-class research training environment for postgraduate students, including an excellent range of support and services.

General information about the Department(s)/Institution(s) can be found at:

Nottingham Biomedical Research Centre: www.nottinghambrc.nihr.ac.uk

School of Medicine: http://www.nottingham.ac.uk/medicine/index.aspx

School of Life Sciences: http://www.nottingham.ac.uk/life-sciences

School of Pharmacy: http://www.nottingham.ac.uk/pharmacy

Arthritis UK Pain Centre: http://www.nottingham.ac.uk/paincentre

Informal enquiries may be addressed to Victoria Chapman Email: victoria.chapman@nottingham.ac.uk.

Applications, with a detailed CV and the names and addresses of 2 referees, should be sent to msk-enquiries@nottingham.ac.uk or Victoria Chapman, School of Life Sciences, Queen’s Medical Centre, Nottingham NG7 2UH. Please quote ref. number at top. Open until filled.

Interviews will take place January 2018.

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Type / Role:

PhD

Location(s):

Midlands of England