Postdoctoral Scientist – Computational Genomics

MRC Laboratory of Molecular Biology

We are looking for somebody to join the group of Dr Julian Gough to work on a project funded by AstraZeneca to work on Blue Skies research on cell fate control in murine models of immune oncology and lung repair.

We have created a system ‘Mogrify’ based on cellular networks to predict transcription factors for reprogramming one human cell type into another (Rackham et al. Nature Genetics 2016). This has been experimentally validated by proving several novel conversions, and we are validating many more. Working closely with AstraZeneca murine models of immune oncology and lung repair we will investigate the use of small molecules for cell reprogramming in mouse. The work is anticipated to be predominantly computational and theoretical but will also include laboratory work in transcriptomics.

Candidates will be highly motivated, have a PhD in a relevant subject, and have an aptitude for theoretical work and data analysis. Candidates should have experience of and ability to perform techniques relevant to the project.  Particularly useful would be experience of computational research. The post is available to applicants with varying computational experience. Applicants with no formal training in computational or mathematical work but who enjoy it, have self-taught to a high level, the aptitude and are keen to learn will be considered, if they have other complimentary biological qualifications, knowledge and experience. Conversely computer or technical scientists with no formal training in molecular biology will be considered if they have a powerful interest and motivation in molecular biology and are driven to learn.

The successful applicant will be awarded a 2 year Career Development Fellowship/MRC Postdoctoral Training Scheme.  The fellowship is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, or is moving into a new research discipline. There will also be the opportunity to work closely with AstraZeneca.

Working for the MRC provides a whole host of benefits including a final salary pension scheme, Benenden Healthcare membership and excellent holiday entitlement. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers. 

The MRC Laboratory of Molecular Biology is one of the birthplaces of molecular biology and is an internationally renowned centre for fundamental biomedical research.

The LMB has a strong track record in training Postdoctoral Fellows who have gone on to become leading Scientists. We also have an excellent record of innovative basic research leading to applications in medicine. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

For further information of the research undertaken at the LMB, please visit:

Informal enquires are encouraged and may be made to Julian Gough at;

To apply and access full details of the vacancy please visit our job board at If you are unable to apply online please contact us at 

Closing date: 9 January 2018

Final appointments will be subject to a pre-employment screening.

The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme

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South East England