Research Associate

University College London - UCL Cancer Institute - Research Department of Cancer Biology

The aim of this post is to study the mechanisms of signalling pathways in cell death, inflammation, immunity and cancer. The research programme in the Centre for Cell Death, Cancer and Inflammation (CCCI) of the Division of Cancer Biology is led by Professor Henning Walczak. The central aspect of the team’s work is to study the biology of cytokines and their receptors and how they regulate cell death, inflammation and immunity and how this is deregulated in cancer and other inflammation-associated diseases. The group focuses on the basic signal transduction mechanisms triggered by members of the tumour necrosis factor (TNF) superfamily (TNF-SF) of ligands and their receptors, as well as other crucial immune receptors and their ligands. A particular emphasis is placed on death receptor–ligand systems and the role of ubiquitination in the signalling pathways they engage with a particular focus on linear ubiquitination. By gaining a better understanding of the processes of, and interplay between, cell death, inflammation and immunity, the Walczak team aims to provide more specific and effective treatment options for patients suffering from inflammation-associated diseases including (auto-)immunity and cancer.

Duties and responsibilities of the post holder include but are not limited to: gain novel insight on signalling pathways triggered by stimulation of TNFR-SF members as well as on their physiological and patho-physiological roles by performing state-of-the-art biochemical, in-vivo, ex-vivo and in-vitro research, establish the necessary analysis systems for the biochemical and functional study of death-receptor ligand systems; attend research seminars and other departmental meetings as required; identify and develop suitable techniques for the collection and analysis of data.

The post is funded until 31st July 2019 in the first instance.

The successful applicant must  have or be studying towards a PhD; substantial experience in the biochemical and functional analysis of signaling complexes and/or pathways, experience with various additional in-vivo, ex-vivo and in-vitro techniques, knowledge of general laboratory practice, techniques and instrumentation are also essential criteria.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £30,316 - £31,967 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

UCL vacancy reference: 1699442

The appointment will be on UCL Grade 7. The salary range will be £34,635 - £41,864 per annum, inclusive of London Allowance.

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button below. For enquiries regarding the application process please contact Laime Matkeviciute(HR Assistant),

Interview Date: TBC

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