PhD Studentship - The Breakdown of Neurovascular Coupling in the Diseased State Specifically Epilepsy and Alzheimer’s Disease

University of Sheffield

Fully Funded PhD Scholarship in Psychology at the University of Sheffield

This is one of many projects in competition for the current funding opportunities available within the Department of Psychology

Project title: The breakdown of neurovascular coupling in the diseased state specifically Epilepsy and Alzheimer’s disease

Primary supervisor: Dr J Berwick

Project description: Epilepsy is the most common neurological condition in the UK, affecting 1 – 2 % of the population. Epilepsies often involve only a small area of the brain - the epileptic focus – and the abnormal activity can propagate out from there. Although surgery is often curative in epilepsy, effective intervention relies on the correct identification of the location of the epileptic focus. Current pre-operative techniques are of limited use in this regard, but the new generation of imaging techniques based on changes in blood perfusion of active areas offer great promise. However, we currently have very little understanding of how epilepsy affects the relationship between brain activity and perfusion. Our research will use state of the art techniques in an animal model of epilepsy to characterise, define and measure the relationship between activity and perfusion in the epileptic state. We will also assess whether any long term changes in this relationship persist after epileptic activity, and whether antiepileptic medication can return the relationship to normal. The research we propose will develop the use of imaging techniques as a tool for pre-surgical localization of epileptic foci in epilepsy and ultimately improve outcomes for surgical interventions on human epilepsy patients.

Research Groups Involved: Dr Berwick, Dr A. J. Kennerley, Prof Overton, Dr CHUANG Kai-Hsiang – Singapore Bioimaging consortium

Start date: 1 October 2018

Requirements: Applicants must have a minimum of a first class or high upper second-class undergraduate honours degree and a distinction or high merit at Masters level in psychology or a related discipline.

Funding: Tuition fees £4,194 per year Living Expenses £14,500.00

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you'll be part of the Science Graduate School. You'll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You'll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit www.sheffield.ac.uk/sgs to learn more.

For further details and the application process please visit:

www.sheffield.ac.uk/postgradapplication

Closing date for applications is 5pm Wednesday 24 January 2018

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Type / Role:

PhD

Location(s):

Northern England