Postdoctoral Research Fellow: Deciphering the molecular mechanisms of novel DNA repair complexes

University of Sussex - School of Life Sciences

Expected start date 1 March 2018 or as soon as possible after this date
Closing date for applications: 11 January 2018

Contract: Fixed term for 2 years
Hours: full time or part-time considered

The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.

Postdoctoral Research fellows: Deciphering the molecular mechanisms of novel DNA repair complexes

Applicants are invited to apply for two BBSRC-funded postdoctoral positions to study novel  DNA repair mechanisms. Cells possess a myriad of DNA maintenance pathways required to ensure genome stability.

The aim of this project is to study the molecular mechanisms of two recently discovered DNA damage repair complexes. Specifically, we would like to identify the components of these repair complexes and define the molecular mechanisms by reconstituting these repair processes in vitro.

Applicants must have extensive experience in using biochemical, biophysical and molecular biology techniques to study the molecular interactions and enzymatic mechanisms of protein complexes involved in DNA / RNA repair, replication, CrispR, transcription or related cellular processes.

The successful applicants will join the Genome Damage and Stability Centre, an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease.

We provide a stimulating and supportive research environment and our expertise covers a wide range of experimental systems. Further information about our research can be obtained from our website at http://www.sussex.ac.uk/gdsc/.

Required qualifications for this position:

  • A PhD in biochemistry, structural biology or equivalent
  • A minimum of one first author publication in a reputable journal
  • Proven track record working on DNA/ RNA metabolising enzymes
  • Advanced skills in biochemistry and molecular biology
  • Highly motivated to work with protein complexes involved in DNA repair
  • Commitment to work in a highly competitive field.
  • Ability to independently drive a research project and analyse data
  • Fluent in written /spoken English and writing scientific reports/papers.

What we offer:

  • A highly motivated and dedicated international team.
  • Innovative projects at the forefront of this research field
  • Excellent collaborative research facilities and environment
  • Collaborations with many labs in our centre and abroad
  • A project where your contribution will make a real impact!

The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award. Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in science and engineering at Sussex.  Part-time working will be considered.

The University offers various schemes to provide real benefits to parents, these can be found at http://www.sussex.ac.uk/humanresources/personnel/familyfriendlypolicies

Potential candidates are strongly encouraged to make informal contact with Prof. Aidan Doherty before applying. E-mail: AJD21@sussex.ac.uk; Tel: +44 1273 877500.

Applications should be accompanied by a full CV, a statement of research interests and aspirations (not more than  a total of 4 pages), and the names of three academic referees.

For full details and how to apply see www.sussex.ac.uk/jobs

The University of Sussex is committed to equality of opportunity

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South East England