Research Fellow in Structure-based Cancer Drug Discovery and Biophysics

University of Leeds - Faculty of Biological Sciences - School of Molecular & Cellular Biology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural biology and biophysical methods, including biomolecular NMR? Do you want to further your career in one of the UKs leading research intensive Universities?

Based in the laboratory of Professor Alex Breeze in the Astbury Centre for Structural Molecular Biology and in collaboration with partners based at Newcastle University (Professor Mike Waring, Department of Chemistry) you will work on the design of allosteric inhibitors of the Ras exchange factor, SOS. 

The project is funded by the Pancreatic Cancer Research Fund and will involve fragment-based compound screening, structural analysis using X-ray crystallography and NMR spectroscopy, and biophysical and computational analysis of binding interactions. Exceptional facilities are available in Leeds to support the project, including a new, 950 MHz cryoprobe-equipped NMR spectrometer and state-of-the-art X-ray crystallography and biophysics infrastructure.

We are looking for a highly multidisciplinary and collaborative Postdoctoral Researcher who has a PhD (or close to completion) in structural biology and has experience in the use of biophysical methods (e.g. SPR, ITC, thermal melt/DSC, MST).

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences gained a Bronze award in 2014 and submitted an application for a Silver award in April 2017. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

To explore the post further or for any queries you may have, please contact:

Professor Alex Breeze, Professor of Biomolecular NMR

Tel: +44 (0)113 343 0087, email:

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Northern England