Postdoctoral Training Fellow in Computational Biology/Bioinformatics

The Francis Crick Institute

Contract: Fixed-term (4 years)/Full time

Short Introduction/Summary

We are seeking a highly motivated and collaborative Postdoctoral Fellow with experience in computational biology/bioinformatics. Our lab seeks to understand gene function and to characterise gene expression during human preimplantation development. We generate genome-wide data sets related to human embryo development and stem cell pluripotency, which require sophisticated computational analyses. The main strategies in the lab involve genomic profiling of early human embryos and microdissected cells and utilizing this data to inform novel strategies for stem cell derivation from embryos and reprogramming using induced pluripotent stem cell approaches.

The post-holder will develop computational and statistical methods necessary to characterise these datasets and to extract relevant biological information.  The position will be based at The Francis Crick Institute in London in Dr Kathy Niakan’s laboratory.

Project Scope/ Description

Dr Niakan’s laboratory focuses on understanding the mechanisms of lineage specification in human embryos and the establishment of novel human stem cells. Details of research projects currently being undertaken can be seen at:  http://www.crick.ac.uk/kathy-niakan  

The research aims are to characterise the modifications that have been generated following genome modification of mammalian embryos. The research also aims to investigate gene expression patterns during human preimplantation development using computational/bioinformatics analysis.

Research techniques used in the laboratory include: next generation sequencing including whole genome sequencing, ChIP-sequencing, single-cell RNA-sequencing and DNA methylation analysis. The post-holder will develop computational and statistical methods necessary to exploit these data sets and to extract relevant biological information. Other techniques in the lab include molecular biology, advanced microscopy and image quantification, human and mouse preimplantation embryo culture and micromanipulation, genome modification, human embryonic and induced pluripotent stem cell derivation.

There are opportunities to gain training in advanced human stem cell culture and molecular biology techniques, should this be of interest to the post-holder.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 05 January 2018 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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London