PhD Studentship: Regulation of neutrophil functions in innate immunity

University of Bristol - Cellular and Molecular Medicine

The project:

We are looking to recruit an enthusiastic and talented PhD student to work under the supervision of Dr Borko Amulic in the School of Cellular and Molecular Medicine. The project will investigate the molecular regulation of neutrophil antimicrobial responses, with a focus on neutrophil extracellular trap (NET) formation. NETs are made of extruded chromatin with antimicrobial and immunomodulatory properties. They are an important part of the innate immune response to pathogens but have also been implicated in non-infectious diseases such as cancer and autoimmunity. The student will work with primary human neutrophils and neutrophil cell lines, and use imaging, biochemical and genetic techniques to explore the role of cell cycle proteins in NET formation. The project is expected to advance our understanding of basic neutrophil cell biology as well as how neutrophils function in diseases such as fungal infections and malaria.

For more information please see:

http://www.cell.com/current-biology/fulltext/S0960-9822(11)00293-4

http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30826-2

Interested and suitably qualified candidates should make informal contact with Dr Borko Amulic (borko.amulic@bristol.ac.uk) before 31 January 2018. The intended start date for the project is September 2018, but there is flexibility. After contacting Dr Amulic, you may be invited to make a formal application by sending a 2-page CV and covering letter explaining why you want to join this PhD program, and then additionally applying using the University of Bristol on-line application system.

The primary supervisor for the PhD will be Dr Borko Amulic and secondary supervisor will be Professor Christoph Wuelfing.

How to apply:

Please make an online application for this project at http://www.bris.ac.uk/pg-howtoapply. Please select Cellular and Molecular Medicine PhD 4yr on the Programme Choice page. You will be prompted to enter details of the studentship in the Funding and Research Details sections of the form. For general enquiries linked to the online application process, please email fbs-pg-admissions@bristol.ac.uk.

Candidate requirements: Applicants should have, or expect to achieve, a first class honours degree (or equivalent; a 2:1 degree qualification would be the minimum) and / or with a research Masters degree in a relevant discipline (e.g. biomedical sciences). Applications are welcome from enthusiastic, self-motivated and high performing candidates.

Funding: Scholarship covers full UK/EU PhD tuition fees and a tax-free stipend at the current RCUK rate (at the standard Research Councils UK rate; currently £14,553 per annum for 2017-18). PhD to commence in September 2018, but there is flexibility.

Contacts: Interested and suitably qualified candidates should make informal contact with Dr Borko Amulic by email at borko.amulic@bristol.ac.uk.

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Advert information

Type / Role:

PhD

Location(s):

South West England