UKRI Innovation/Rutherford Fund Fellowship

MRC London Institute of Medical Sciences

Fixed-term, 3 years

A 3-year postdoctoral position is available at Imperial College London and the MRC London Institute of Medical Sciences (LMS) to work in the Molecular Systems group headed by Dr Tobias Warnecke. You will also closely interact with the Computational Protein Biology group led by Joe Marsh at the MRC Human Genetics Unit, University of Edinburgh.

We are looking for an outstanding postdoctoral scientist to work on an exciting project at the intersection of medical population genetics, molecular evolution, and protein structural biology. The project is aimed at modelling and predicting the joint impact of two or more amino acid variants on protein structure and protein complex formation, using globinopathies as a model system. We want to explore how naturally occurring variants, obtained from large population cohorts, interact at the structural level when combined on a single genetic background, to obtain view of population-wide epistatic potential and to allow individualized disease predictions that can be tested experimentally.

The project requires extensive computational modelling of protein structure and interactions so advanced working knowledge of state-of-the-art modelling software is highly desirable. You should be proficient in at least one programming/scripting language (java, python, etc.) as well as R or Matlab and comfortable with carrying out large-scale analysis in a computing cluster environment. Candidates must have a strong publication record, excellent verbal and written communication skills, and a track record of addressing scientific problems in an innovative, thoughtful and systematic manner. Prior knowledge of haemoglobin and/or red blood cell biology is a bonus.

You will hold a UKRI Innovation Fellowship (UK nationals) or a Rutherford Fund Fellowship (non-UK nationals) and be part of a national cohort of fellows funded by the UK Government’s Industrial Strategy fund. Locally, the fellow will be part of a diverse computational/experimental research team with expertise and wide-ranging interest in epigenetics, systems biology, and molecular evolution ( In addition, the fellow will benefit from close interaction with the Marsh group in Edinburgh ( Dedicated support and career advice will be available through Imperial’s Postdoc Development Centre.

Please contact Dr Warnecke for further information about the post (

For full details of this post and to complete an online application, visit and upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number LMS – 733.

Closing date: 25 January 2018

Final appointment will be subject to pre-employment screening

*Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

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