Senior Staff Scientist - Germ Free/Gnotobiotic Facility

Wellcome Trust Sanger Institute

Fixed term for 3 years

We are seeking a talented, motivated and experienced Senior Staff Scientist at the Wellcome Trust Sanger Institute, under the leadership of Dr Trevor Lawley ( We are expanding the germ free/gnotobiotic capability for controlled-microbiome studies, and are looking for a Senior Staff Scientist to work closely with Dr Trevor Lawley and other members of the Sanger Institute, to provide operational and scientific leadership.

This is an exciting opportunity for the successful candidate to join a dynamic team investigating the role of the microbiota in human health and a variety of diseases, such as autoimmunity, infections and cancers, using genomics, microbiology and model organisms. There is a strong translational focus to the Lab with the goal of developing novel, microbiome based diagnostics and therapeutics.

The successful applicant will have experience in designing and executing mouse experiments and managing mouse colonies. Key responsibilities include, facilitating and building a strong host-microbiota interactions programme to build on the current understanding of the interactions with disease areas such as cancer, immune system modulation, and infection. The successful candidate will be part of a multidisciplinary, collaborative team and will be expected to work closely with existing team members to accomplish scientific objectives and proactively identify, establish and develop new collaborations and new projects and publications.

You will have substantial opportunities for learning and development, working closely with informaticians, wet-lab biologists, Postdoctoral Fellows and PhD students.

Essential Skills

  • PhD with strong background in mouse immunology, genetics, infections or cancer
  • Demonstrated research experience, such as publications in peer-reviewed journals
  • Holder of a Home Office Personal Licence or an equivalent licence outside the UK
  • Experience of planning research projects
  • Experience writing COSHH assessments and Biological Risk Assessments
  • Supervisory experience including training and guiding others
  • Ability to organise own workload and that of team
  • Excellent organisational and problem-solving skills
  • Team player with ability to effectively prioritise, multi-task and work independently
  • Ability to review, synthesise, and present scientific data and methods
  • Excellent writing and verbal communication skills
  • Demonstrated track record of analysing and interpreting large datasets and delivering complex scientific projects through to publication
  • Enthusiasm, commitment and attention to detail
  • Experience presenting to outside groups
  • Proven ability to develop and maintain effective working relationships, particularly with scientific users
  • Effective communicator with wide range of persons of differing levels, abilities and knowledge

Other information

The Wellcome Trust Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Genome Research Limited is an Equal Opportunity employer. We will consider all qualified applicants without discrimination.

Please include a CV and application letter.