Postdoctoral Research Assistant

University of Dundee - Gene Regulation and Expression

Closing date: 09 February 2018

The laboratory of Dr. Federico Pelisch is seeking a highly motivated postdoctoral applicant to study how the Small Ubiquitin-related Modifier (SUMO) regulates protein complexes during cell division. Specifically, the project focuses on the cross-talk between SUMOylation and phosphorylation during meiosis, with an emphasis on understanding how the balance between SUMO E3 ligases and proteases as well as kinases and phosphatases is achieved in vivo. The project will use mainly the nematode C. elegans as a model, but mammalian systems will also be used. To tackle these issues, a wide range of techniques will be used, including proteomics, biochemical assays, genome editing, and different imaging methodologies.

The Pelisch lab is situated in the Centre for Gene Regulation and Expression (http://gre.dundee.ac.uk/) within the School of Life Sciences.

Pelisch et al, A SUMO-dependent protein network regulates chromosome congression during oocyte meiosis. Molecular Cell (2017), 65:66-77.

Pelisch, F.* & Hay, R.T. Tools to study SUMO conjugation in C. elegans. Methods Mol Biol. 2016;1475:233-56. doi: 10.1007/978-1-4939-6358-4_17.

Pelisch et al, Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nature Communications (2014) Dec 5;5:5485. doi: 10.1038/ncomms6485.

Candidate requirements:

  • PhD with outstanding academic track record.
  • Strong background in biochemistry and cell biology.
  • Strong experience in at least one of the following is essential: i) ubiquitin/SUMO biochemistry; ii) live cell imaging or single molecule fluorescence techniques; iii) C. elegans biology.
  • Capable of working in a team, but able to plan and work independently.
  • Excellent communication skills and knowledge of the English language.
  • Willingness to learn and apply new techniques across a broad range of disciplines and to adapt/develop novel approaches where required.
  • Motivation, creativity and ability to communicate and to work with others.

This position is available for a period of three years in the first instance.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).

Additional Information

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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