Postdoctoral Research Associate in Chromatin-mediated Silencing of Endogenous Human Retroelements

University of Cambridge - Cambridge Institute for Medical Research - Medicine

Applications are invited for an enthusiastic, motivated individual for a Wellcome Trust funded postdoctoral position in the group of Professor Paul Lehner at the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus, University of Cambridge

You will join an exciting research programme using genetic and proteomic approaches to understand chromatin-mediated silencing of endogenous human retroelements, with specific reference to the novel HUSH epigenetic transcriptional repressor complex (Tchasovnikarova IA et al Science (2015) 348:1481-5, Nature Genetics (2017) 49:1035-1044, et Liu al Nature Dec 6 (2017)) which is responsible for chromatin-mediated repression of cellular transgenes and newly integrated retroviruses.

This post will involve the use of cutting edge genetic, biochemical, proteomic and bioinformatic techniques to study mechanisms of retroviral silencing. Candidates should have a PhD with experience in virology or chromatin biology, in chromatin biochemistry and cell biological techniques. Quantitative and analytical skills, as well as expertise in bioinformatics are also desirable. If you have an excellent background in biological sciences, have published in high impact journals, are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you.

Applicants should have excellent organisation and communication skills, and work well as part of a team.

Fixed-term: The funds for this post are available for 3 years in the first instance with an immediate start date.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

For further details or informal enquires please contact Paul Lehner via email (

Please quote reference SC14458 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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South East England