Post doctoral Research Associate - Bioinformatician

University of Cambridge - Cambridge Institute for Medical Research - Medicine

Applications are sought for a talented Bioinformatician to join the highly-collaborative research team of Professor Paul Lehner, at the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus, University of Cambridge. You will join an exciting research programme using genetic and proteomic approaches to understand chromatin-mediated silencing.  Specifically, how retroviruses and endogenous human retrotransposons are regulated through epigenetic pathways (Tchasovnikarova IA et al Science (2015) 348:1481-5, Nature Genetics (2017) 49:1035-1044, et Liu al Nature Dec 6 (2017)).

Our work encompasses: (i) computational analyses of novel data sets generated from a range of technological platforms including genome-wide CRISPR forward genetic screens, ChIP-seq; RNA-seq, whole-exome sequencing (WES) (ii) systematic quantitative proteomic analysis of TMT-labelled whole cell extracts. Candidates should have extensive independent experience in analysing ChIP-seq and RNA-sequencing data, programming skills using Perl and Python as well as bioinformatic data processing experience. Practical experience in handling, interpreting and visualising genetic datasets is essential, proteomic datasets would also be of value. In addition you will develop new interactive tools for data analysis and instruct and assist laboratory members in analysing their data and designing experiments. Applicants should have excellent organisation and communication skills, and work well as part of a team.

Employment will be part time (50%) 18.5 hours per week and flexibility is offered regarding days and times worked. 

Fixed-term: The funds for this post are available for 18 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

For further details or informal enquires please contact Paul Lehner via email (

Please quote reference SC14781 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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South East England