Bioinformatician, Cancer Metabolism

The Francis Crick Institute

Contract: Fixed-term (3 years), Full time

Short Summary

A post for a bioinformatician in the laboratory of Mariia Yuneva is available. We are looking for a proactive, imaginative, productive and collegial individual to carry out the research on the role of metabolism in cancer using in vivo models. The project is a part of CRUK Grant Challenge Award funded program and aims to use metabolic modelling and multi-omics dataset analysis to evaluate the relationship between metabolism, genetic lesions and cellular composition in mouse models, patient cancer samples and ex vivo models derived from them.


The successful applicant will use metabolic modelling and flux analysis, will design experiments in collaboration with wet-lab scientists and integrate experimental data including transcriptomics, proteomics, metabolomics and mass spectrometry imaging. For more information about this research, please visit Yuneva’s lab external website: and CRUK Grand Challenge website:

The successful applicant will have good communication and organisational skills and a PhD in Computational Biology, Bioinformatics, Biochemistry or similar. Experience in the following is required: metabolic modelling, flux analysis and integrating multi-dimensional omics. Experience with metabolic modelling in mammalian systems is a plus.

About Us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 19 March 2018 at 23:30.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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