Postdoctoral Training Fellow in Computational Biology/Bioinformatics

The Francis Crick Institute

Contract: Fixed-term (4 years)/Full time

Short Introduction/Summary

We are seeking a highly motivated and collaborative Postdoctoral Fellow to develop computational approaches for characterizing genome-wide changes to genetically modified embryos and embryonic stem cells using next generation sequencing. The fellow would also use computational approaches to understand the logic of signalling and transcriptional control in human embryos and stem cells using single-cell combined transcriptome and DNA methylation analysis.

The post-holder will develop computational and statistical methods necessary to characterise these datasets and to extract relevant biological information.  The position will be based at The Francis Crick Institute in London in Dr Kathy Niakan’s laboratory.

Project Scope/ Description

Dr Niakan’s laboratory focuses on understanding the mechanisms of lineage specification in human embryos and the establishment of novel human stem cells. Details of research projects currently being undertaken can be seen at: 

Research techniques used in the laboratory include: next generation sequencing including whole genome sequencing, ChIP-sequencing, single-cell RNA-sequencing and DNA methylation analysis. The post-holder will develop computational and statistical methods necessary to exploit these data sets and to extract relevant biological information. Other techniques in the lab include molecular biology, advanced microscopy and image quantification, human and mouse preimplantation embryo culture and micromanipulation, genome modification, human embryonic and induced pluripotent stem cell derivation.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 16 April 2018 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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