Research Fellow in Carbohydrate Nanochemistry

University of Leeds - School of Chemistry

Are you an experienced carbohydrate chemist looking for your next challenge? Are you interested in expanding your research to nanochemistry to address important protein-sugar interactions underpinning virus and bacterial infections? Do you want to further your career in one of the UK’s leading research intensive universities?

We are looking for a Research Fellow to join our multidisciplinary team working on a BBSRC funded project to develop glycan-functionalised fluorescent quantum dots (QDs) as novel multifunctional probes to dissect multivalent protein (DC-SIGN & DC-SIGN/R)-glycan interactions.

Working closely with the Research Fellow in Protein Biochemistry, you will investigate how monovalent carbohydrate binding and presentation affect the multivalent binding affinity and specificity between QD-glycan and DC-SIGN/R and develop potent, specific inhibitors against their receptor-mediated pathogen infections. This will involve synthesising, purifying and characterising a series of specifically designed glycan ligands with varying levels of monovalent binding affinity. You will also make compact polyvalent glycan-QD probes; quantify the QD-protein binding affinity, kinetics and thermodynamics via fluorescence and other biophysical methods (e.g. ITC, SPR) to evaluate their binding specificity; and develop multiple QD-glycan assemblies as virus mimetics to study their interaction and stimulation of dendritic cell maturation (via collaboration).

You will have a PhD in Synthetic Carbohydrate Chemistry, the ability to carry out complex carbohydrate synthesis experiments independently and excellent research skills. You will also have a good knowledge of nanochemistry and biophysical techniques.

To explore the post further or for any queries you may have, please contact:

Dr Dejian Zhou, Senior Lecturer, Tel: +44 (0)113 343 6230, Email:

Location: Leeds - Main Campus

Faculty/Service: Faculty of Mathematics & Physical Sciences

School/Institute: School of Chemistry

Category: Research

Salary: £32,548 to £38,833 p.a. Due to external funding restrictions, an appointment will not be made above £32,548 p.a.

Working Time: 37.5 hour per week

Contract Type: Fixed Term (36 Months)

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Northern England