Research Fellow in Classical and Quantum Computational Studies of Membrane Proteins

University of Southampton - Computational Systems Chemistry

We are seeking to appoint a highly motivated and ambitious postdoctoral researcher to work on an exciting new project on the development and application of protocols to study membrane embedded enzymes using quantum and classical mechanics methodologies. Membrane proteins present a challenge to computational methods, given the environments involved (both membrane and aqueous environment need to be considered). This is particularly challenging for quantum calculations, as the effect of the environment (protein, membrane, water) needs to be included. To understand the mechanisms of action of these enzymes, is it necessary perform large-scale quantum mechanical calculations from first principles. Therefore, in this project, the researcher will work together with the groups of both Professor Syma Khalid and Professor Chris-Kriton Skylaris to bring together their respective expertise to develop a set of robust protocols for the study of membrane embedded enzymes using classical and quantum computational methodologies. 

The position is available for 36 months in total, with appointment initially for one year, which will be extended subject to satisfactory performance.

The University of Southampton, is an institution in the top one per cent of world universities* and one of the UK’s top 15 research-intensive universities with an international reputation for research, teaching and enterprise activities. * QS World University Rankings 2018

You will hold a PhD** or equivalent professional qualifications and experience in computational chemistry, biophysics or physics with a strong background in computational methods for molecular-level calculations. Experience with DFT calculations is essential. 

**Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon successful completion of the PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given.

For informal enquiries, please contact Syma Khalid ( 

Application procedure:

You should submit your completed online application form at The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Elsa Samwell (Recruitment Team) on +44 (0) 23 8059 2507. Please quote reference 982218EB on all correspondence. 

Please note: The University will be closed from close of business on Thursday 29th March 2018 to Thursday 5th April 2018, so we will not be able to assist you with any application queries during this time.

Further details:

We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.

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South East England