Research Associate - Genome Editing Specialist

University of Cambridge - Cancer Research UK Cambridge Institute

At CRUK Cambridge Institute, we perform world leading science which focuses on positively impacting cancer patients' lives. In the Pre-Clinical Genome Editing team, our mission is to make meaningful advances to understand and treat cancer. We use cutting edge technologies to create authentic models of disease for study, and to gain novel biological insight.

As a Genome Editing Specialist, you will expand the capability of our specialised Genome Editing team, allowing us to deliver a broader spectrum User-driven projects. You will also aggressively drive the innovation and application of Genome Editing technologies in translational research. A key focus will be to establish and translate emerging or novel technologies to an in vivo setting, prototyping and working up new methodologies in vitro, and building upon our functional genomics capabilities.

The Pre-Clinical Genome Editing team consists of three sub-teams: Genome Editing, Transgenics, and Pre-Clinical Therapeutics. You will complement the CRISPR capability of our Genome Editing and Transgenics teams, allowing us to better deliver User-defined projects, and work with all three sub-teams to develop novel technologies to model and interrogate the molecular basis of disease both in vitro and in vivo. You will work in an interdisciplinary, collaborative and innovative environment to support CRUK CI's mission.

Key Responsibilities:

You will complement our Genome Editing capability by:

- Utilising advanced in vitro technical skills to complement our existing CRISPR capability, thus allowing us to better deliver User-defined projects
- Working collaboratively with the Pre-Clinical Genome Editing team and Users to design and execute strategies that will answer important biological questions
- Utilising your specialist knowledge to apply emerging technologies to translational research, in vitro and in vivo
- Displaying leadership in the development of novel technologies that exploit CRISPR, and applying these to translational research

Minimum Requirements:

- A PhD or equivalent
- Demonstrable evidence of driving a research project in an autonomous fashion
- Expertise in genome editing technologies is essential (preference is given to expertise in dCas9-based approaches, base editing, and non-SpCas9 CRISPR systems)
- Expertise in advanced molecular techniques (eg Cell Culture, Viral Vectors, Gibson assembly, recombineering)
- Experience of Synthetic Biology and simple model organisms is essential
- Experience with library screening and NGS highly desirable
- Statistical computation (eg R) fluency
- Experience of in vivo Genome Editing desirable (any model organism system)
- Ability to work independently and as part of a hard-working, motivated and enthusiastic team.
- Proactive and flexible, with a proven ability to perform under pressure.
- Excellent and effective communication skills are essential to this role.

Candidates may be required to occasionally work outside of normal working hours.

Fixed-term: The funds for this post are available for 2 years in the first instance, with the possibility of extension to 3 years.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

The closing date is 29th April 2018, with the interview date likely to be week commencing 7th May 2018.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW15203 on your application and in any correspondence about this vacancy.

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