Research Associate (Bioinformatics): Regenerative Cardiovascular Medicine (Fixed Term)

University of Cambridge - Department of Medicine

We are looking to appoint a postdoctoral Research Associate to join the team of Dr Sanjay Sinha (https://www.cardiovascular.cam.ac.uk/directory/ssinha). The position is funded through the BHF Centre of Regenerative Medicine (https://www.cardiovascular.cam.ac.uk/research/oxbridgecrm), one of three national research hubs specialising in cardiovascular regeneration. Membership of the Centre provides a unique opportunity to collaborate with researchers across the partnership (Universities of Bristol, Cambridge, Leeds, Manchester, and Oxford) and with the Imperial and Edinburgh -led Centres.

The Sinha group studies human epicardium’s contribution to heart regeneration after injury. We have pioneered the generation of epicardium from human embryonic and induced pluripotent stem cells (Iyer et al., Development 2015;142:1528-41). We use this in vitro system to understand the molecular regulation of epicardial function, and to produce cells and identify potential new drugs for regenerative medicine.

The focus of this exciting position will be to analyse data obtained from single-cell multi-omics methods, including transcriptomics, epigenetics marks and chromatin accessibility, applied to the in vitro generated epicardium, human foetal epicardium samples and mouse or zebrafish pre- and post-infarction hearts. The successful applicant will work closely with Dr Nicolas Le Novère at the Babraham Institute (https://lenoverelab.org/) and with Professor Paul Riley (https://www.dpag.ox.ac.uk/team/paul-riley) and Professor Ludovic Vallier (https://www.cardiovascular.cam.ac.uk/directory/lvallier).

The successful applicant will have a PhD or equivalent with a background in bioinformatics and a publication record. Experience with the analysis of NGS data is essential, as are programming skills, in particular in R and Python. It is important that you have excellent written and communication skills, are organised and have the ability to work collaboratively with experimental and computational colleagues.

The Sinha group is a member of the Wellcome Medical Research Council Cambridge Stem Cell Institute - an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments. The Institute currently comprises 29 research groups based across six sites in Cambridge. In 2018, all research groups will move to a new building on the Cambridge Biomedical Campus.

Please contact Dr Sanjay Sinha (ss661@cam.ac.uk) or Dr Nicolas Le Novère (nicolas.lenovere@babraham.ac.uk) for informal enquiries.

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date for applications is the 2nd May 2018, with interviews yet to be confirmed by the department.

Please quote reference RC15211 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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