Research Associate

Cardiff University - Division of Infection and Immunity - Cardiff University School of Medicine - College of Biomedical and Life Sciences

A postdoctoral position is available in the laboratory of Professor Andrew Sewell. The proposed project aims to develop the next generation of new T-cell therapies for cancer with a special emphasis on breast cancer. We are at the forefront of developing new technologies in this field and have recently collaborated with Autolus to develop new approaches to T-cell malignancies (Nature Medicine Dec 2017) and improved the function of engineered T-cells via ‘T-cell receptor replacement’ (Blood January 2018). Other recent successes include the world’s first truly synthetic non-biologic vaccine (Journal of Clinical Investigation in press). The aim of this post is to develop non-HLA-restricted, anti-cancer T-cell receptors towards clinical application.

You will be a team player with a PhD or equivalent qualification in immunology, biochemistry, or a relevant science discipline, or expect to gain such a qualification by May 2018. It will be advantageous if you have some relevant experience in a range of relevant immunological and molecular biological techniques including: Flow cytometry, PCR, T-cell culture, TCR gene transfer, TCR sequencing/repertoire analysis, and CRISPR gene editing. We also welcome applicants with protein structure/biophysics experience. We have expertise in all the above techniques so can provide training to the right talented individual that wishes to move field. All seven of the laboratory’s former postdocs have succeeded in obtaining their own independent funding with two now Full Professors at other universities and two acting as Senior Group Leaders in the industrial setting. Consequently, this position could provide a good career steppingstone in a current very ‘hot topic’.

The successful candidate must show a willingness to develop skills in other laboratory techniques and to help supervise a team of graduate students and research staff. The ideal person will be expected to supervise a team of three or more junior individuals in this area within a year of starting.

The role may include some national and international travel for the purposes of learning techniques, data collection, and/or presentation of findings.

The post is available until 31st March 2021, starting April 2018 (with some flexibility on the start date up to June 1st).

Further details about the group can be found at www.tcells.org.

Informal enquiries by email are welcomed by Prof. Sewell at SewellAK@cardiff.ac.uk.

Our recent publications are listed at http://www.tcells.org/scientific/andysewell/publications/.

This post is a full time (35 hours per week) fixed term position available from 1st April 2018 until 31st March 2021.

Salary: £32,548 - £38,833 per annum (Grade 6), but please note that it is anticipated the maximum starting salary for this post will be £36,613 per annum, point 34.

Date advert posted: Wednesday, 4 April 2018.

Closing date: Saturday, 22 April 2018.

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural, and economic obligation to Cardiff, Wales, and the world.  In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

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