Laboratory Manager/Technician

MRC London Institute of Medical Sciences

Fixed Term, 1 Year

Work to support investigations led by Dr William Scott (Chain-Florey Clinical Lecturer in Diabetes and Endocrinology) in collaboration with the Metabolic Signaling and Cellular Stress Groups at the MRC LMS led By Professors Dominic Withers and David Carling. The LMS is a leading MRC research institute at Imperial College London, based on the Hammersmith Hospital campus. For more information, please visit

A fundamental goal of biomedical research is to understand why some people are more likely than others to develop serious medical conditions such as obesity and diabetes. Our primary objective is to define molecular genetic and epigenetic mechanisms which contribute to differences in obesity and metabolic disease susceptibility. We use: i. high-throughput molecular profiling strategies to identify putative disease mechanisms in isolated metabolic cells from affected humans and animal models; ii. genetic manipulation in experimental systems to examine the molecular, cellular and organismal functions of our discoveries. This approach has led to the identification of alterations in human adipocyte DNA methylation and gene transcription which are linked to obesity and reside in key metabolic and inflammatory genes. The project aim is to carry out functional screens of implicated candidate genes first in primary human cells then in animal models; integrating information from cellular and molecular biology, microscopy, genomics, proteomics and physiology. You will provide technical support for starting up the lab, ongoing scientific experiments within the group and as act as a general lab manager. Responsibilities at the bench will include cell culture, plasmid preparation and lentiviral production, quantitative PCR, western blotting, microscopy, isolation of adipocytes and inflammatory cells from tissue, genotyping and phenotyping.

You should have excellent communication, organizational and research skills, a strong work ethic and attention to detail, meticulous record keeping, and a positive attitude to learning and trouble-shooting new methods. Please refer to the Job Description and Person Specification online for further information about the position.

For full details of this post and to complete an online application, visit and upload your CV, names and contacts of three scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number LMS – 807.

Closing date: 29 April 2018

The Medical Research Council is an Equal Opportunities Employer

Final appointment will be subject to pre-employment screening.

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