Research Fellow (Postdoc Position in Breast Cancer Genetics)

Trinity College Dublin, The University of Dublin - School of Genetics and Microbiology

Post Specification

Post Status: Specific Purpose Contract (approx. 2-3 years)
Research Group / Department / School: Adrian Bracken Research Group, Smurfit Institute of Genetics, School of Genetics and Microbiology.
Location: Smurfit Institute of Genetics, Trinity College Dublin, the University of Dublin, College Green, Dublin 2, Ireland
Reports to: Professor Adrian Bracken
Salary: Salary will be between €37,000 - €48,000 Appointment will be made depending on experience on at a point in line with Government Pay Policy
Hours of Work: 37 hours per week
Closing Date: 18.00 (Irish Standard Time), Wednesday, 25th April 2018

PLEASE NOTE: The project start date will be mid-late 2018 (depending on availability) and run for approx. 2-3 years.

Post Summary

A Postdoc position is now open in the laboratory of Professor Adrian Bracken to study novel non-coding mutations in familial breast cancer at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland.

Background and aim of the project:

Mutations in BRCA1, BRCA2 and several other genes account for only 25% of familial breast cancer. We performed targetted DNA sequencing of non-BRCA1/2 cases of breast cancer and identified many additional mutations in both the coding exons, and interestingly, also the non-coding promoters and enhancers of several known oncogenes and tumour suppressors.

This project will investigate a selection of the novel potentially causative mutations in the non-coding regulatory regions near the BRCA2, ATM, PIK3CA, PIK3R1, EGFR, ERBB2, TERT, TP53, GADD45A and BRAF genes, which we hypothesise predispose women to breast cancer. The objective of this Postdoctoral project will be to characterise the consequences of these mutations by using CRISPR to generate isogenic breast cancer cell line models to study their biology.

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Republic of Ireland

* Salary has been converted at the prevailing rate on the date placed