Development of a human stem cell model of pain to identify a new generation of non-opioid analgesics

University of Greenwich - Faculty of Science and Engineering, Medway Campus

The Laboratories of Stem Cell & Gene Editing (University of Greenwich) and Neurophysiology (University of Kent) have an open position for a PhD student. The position is fully funded for three years by a Vice Chancellor PhD scholarship from the University of Greenwich and begins in Fall 2018. The successful candidate will work in close collaboration with the Fivaz and Mathie Labs to develop and validate new stem cell-derived models of pain. This PhD project involves the use of CRISPR-Cas9 gene editing in human pluripotent stem cells (hPSCs) to introduce human mutations in ion channels implicated in pain signalling. Sensory (pain-sensing) neurons will then be generated from these hPSCs and their response to noxious stimuli will be examined using both imaging and electrophysiological approaches. The long-term objective of this project is to identify novel non-opioid painkillers. Previous exposure to molecular biology, stem cell biology or neurobiology is a plus but not a requirement. This research will be carried out in renovated lab space with access to state-of-the-art microscopy and electrophysiology platforms. The University of Greenwich (Medway campus) is situated in beautiful Kent county, an hour away from London. Interested candidates should send a one page cover letter justifying their interest and motivation to work in this area of research, along with their cv to m.l.fivaz@gre.ac.uk and a.a.mathie@kent.ac.uk

Bursary available (subject to satisfactory performance):

Year 1: £14,777           Year 2: In line with RCUK rate      Year 3: In line with RCUK rate

The successful candidate will receive a contribution to tuition fees equivalent to the university’s Home/EU rate, currently £4,260, for the duration of their scholarship. International applicants will need to pay the remainder tuition fee, currently £9,240, for the duration of their scholarship. This fee is subject to an annual increase. Scholarships are available for three years, full-time study from the date scholars first register as an MPhil/PhD student with the university. Applicants must meet the programme entry requirements. 

For additional information about the scholarship please go to: http://www2.gre.ac.uk/research/study/studentships 

Please read this information before making an application. Applications need to be made online via http://www2.gre.ac.uk/research/study/apply/application_process   No other form of application will be considered.

All applications must include the following information.  Applications not containing these documents will not be considered.

  • Scholarship Reference Number (Ref) – included in the personal statement section together with your personal statement as to why you are applying
  • a cover letter*
  • a CV including 2 referees *
  • academic qualification certificates/transcripts and IELTs/English Language certificate if you are an international applicant or if English is not your first language or you are from a country where English is not the majority spoken language as defined by the UK Border Agency *

*upload to the qualification section of the application form. Attachments need to be in PDF format.

The closing date for applications is midnight (UTC) on June 15, 2018

The scholarship must commence before October 31, 2018.

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Type / Role:

PhD

Location(s):

South East England