|Funding for:||UK Students, EU Students|
|Hours:||Full Time, Part Time|
|Placed On:||28th August 2018|
|Closes:||26th October 2018|
PhD Studentship available full-time or part-time
Start date: 1 January 2019
Director of Studies: Dr Xin-peng Dun
2nd Supervisor: Professor David Parkinson
3rd Supervisor: Dr Xinzhong Li
The Faculty of Medicine & Dentistry are seeking to appoint PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally rated research. The Faculty is committed to research excellence with a recent £25 million investment in staff and facilities. Medical research here was ranked first for outputs in REF2014.
Our lab is interested in regenerative biology and how the peripheral nervous system may repair itself following injury; our aim is to boost the repair of such injuries in human patients to provide a better clinical outcome. In this PhD, we will use molecular biology techniques to create expression vectors carrying engineered Netrin-1, an axon guidance molecule. The binding properties of the mutated Netrin-1 protein on Netrin-1 attractive and repulsive receptors will be verified by co-immunoprecipitation and western blot. Validated vectors will be used to produce adeno-associated virus for Schwann cell infection and in vivo delivery in a rat sciatic nerve injury model. Functional recovery will then be studied to measure the effect of the modified Netrin-1 protein on peripheral nerve repair. The successful candidate also have chance to use Netrin-1 and DCC conditional knockout mouse models and study how Schwann cell derived Netrin-1 promotes peripheral nerve regeneration. For further information regarding the project, please see (International Journal of Molecular Sciences, 2017, 18(3), 491) or contact Dr Xin-peng Dun.
Candidates will be shortlisted against the following criteria:
The studentship is supported for 3 years and includes full Home/EU tuition fees plus a stipend of approximately £14,777 p.a. The studentship will only fully fund those applicants who are eligible for Home/EU fees with relevant qualifications. Applicants required to cover international tuition fee rates will have to pay the difference between the Home/EU and international fee rates. For the 18/19 academic year, the difference is £10610. If you are selected you will be required to provide financial assurances.
To Apply: Access the application form and further information on the admissions process on our applicant and enquirers page. Please mark the application with REF: 17-18-015R2 for the attention of Francesca Niedzielski. A project proposal is not required.
If you have any questions contact firstname.lastname@example.org
The University of Plymouth is committed to equality of opportunity, promoting a diverse and inclusive culture, demonstrated through our commitment to the gender equality Athena SWAN Charter and as a Stonewall diversity champion. All applications will be judged solely on merit; however, we particularly welcome applications from currently under-represented groups.
The closing date for applications is 12pm on Friday 26th October 2018. Shortlisted candidates will be invited for interview after the closing date. Applicants who have not received an offer of a place by Friday 16th November 2018 should consider their application has been unsuccessful on this occasion.
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