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Senior Biophysics Scientist

The Beatson Institute for Cancer Research

Location: Glasgow
Salary: Starting Salary £24,776 - £41,536, depending on experience
Hours: Full Time
Contract Type: Permanent
Placed On: 14th September 2018
Closes: 31st October 2018

The Drug Discovery Unit at the CRUK Beatson Institute in Glasgow, is one of five Cancer Research UK funded Drug Discovery teams across the UK.  These teams aim to work closely with local cancer experts to develop new and innovative therapies that strike at the core of cancer pathology.  Using current screening and structural sciences/biophysics technologies, industry standard medicinal chemistry and complex biological modelling systems, the Drug Discovery Group at the Beatson is tackling some of the most challenging targets in cancer biology.  

We currently have an exciting opportunity as a consequence of the expansion in our drug discovery portfolio.  If you are a highly skilled, enthusiastic individual who takes an innovative and proactive approach to research challenges, then we would like to hear from you.

We are looking for a talented and motivated scientist who will take a central role as a biophysicist in our structural sciences team.  The successful applicant will use a range of techniques, including SPR, to identifiy and characterise molecular interactions using our state of the art biophysics capabilities.

Playing an influential role in our drug discovery projects, you will work collaboratively with all teams (biophysicists, protein scientists, crystallographers, biologists and chemists) at the Beatson and wider CRUK network to help formulate innovative and forward thinking approaches towards tackling exciting and challenging drug target classes. 

The role requires you to develop and use novel SPR & other biophysical assays to characterise protein ligand interactions, applying these to medicinal chemistry-driven projects at all stages from fragment-based hit identification through to lead optimisation.  The quality data that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.

In addition, you will contribute to the development of the biophysics discipline by identifying and driving improvements and innovations that advance drug discovery projects.

Skills & Experience:

  • A BSc or PhD in Biophysics, Biochemistry or a related discipline.
  • Experience of SPR for measuring protein-ligand interactions is highly desirable.
  • Experience of additional biophysical techniques (e.g. ITC) along with a solid understanding of protein science and enzymology is also desirable.
  • Experience of working in a drug discovery environment where structural and biophysical studies are central to the progression of medicinal chemistry strategies would be an advantage.
  • Excellent communication and leadership skills, including experience of working as part of multidisciplinary team.

In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of biophysics, cancer biology and drug discovery; providing you the opportunity to make a real difference to the lives of cancer patients.

Applications must be made via our website at

Informal enquiries are welcome and should be addressed to Dr Justin Bower;

Closing date for applications is 31st October 2018.

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