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MSC Early Stage Researcher (PhD student) on Bioorthogonal Catalysis and Medicinal Chemistry

The University of Edinburgh - Innovative Therapeutics Lab

Qualification Type: PhD
Location: Edinburgh
Funding for: EU Students
Funding amount: ARC £27,053
Hours: Full Time
Placed On: 4th October 2018
Closes: 26th October 2018
Reference: 045513
 

Project description:

The Innovative Therapeutics Lab (University of Edinburgh) is looking for two Early Stage Researchers (PhD students) to carry out a project at the interface of bioorthogonal catalysis and medicinal chemistry. The project will build on previous success in the development and bio-independent release of caged drugs and probes with catalyst-loaded devices (Refs 1-4). The research will be carried out in the framework of the Marie Sklodowska-Curie European Training Network THERACAT (H2020-MSCA-ITN-2017, Project 765497), which has the objective to train a new generation of early stage researchers on new catalysis-based cancer therapies. The project would suit students with general interests in chemical biology, metal catalysis, medicinal chemistry and translational research.

Requirements for candidates:

Candidates should hold or expect to obtain a first-class honours degree (or a upper-second class with industry experience) in Chemistry, Pharmaceutical Sciences or a related discipline. Lab experience in organic synthesis, metal catalysis and/or medicinal chemistry via honours project, a year in industry or MSc by Research will be highly valued. The candidate will need to submit a cover letter and a 2-page CV including the details of two reference contacts to Asier.Unciti-Broceta@igmm.ed.ac.uk

Marie-Curie fellowship Mobility requirement:

To be eligible for the position you may NOT have been resident in the UK for more than 12 months in the past three years and may have a maximum of four years full-time equivalent research experience and not have been awarded a doctoral degree.

Selected references:

  1. Bray et al. Bright insights into Palladium-triggered local chemotherapy. Chemical Science 2018, DOI: 10.1039/C8SC02291G.
  2. Pérez-López et al. Gold-Triggered Uncaging Chemistry in Living Systems. Angewandte Chemie Int. Ed. 2017, 56, 12548-12552.
  3. Rubio-Ruiz et al. Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor. Journal of Medicinal Chemistry 2016, 59, 9974-9980.
  4. Weiss et al. Extracellular Pd-catalyzed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally-activated prodrug approach. Nature Communications 2014, 5, 3277.

For further information about the research of the host group and the supervisor, please see:

www.ed.ac.uk/cancer-centre/research/unciti-broceta-group

www.boomchemistry.com

For more information and to submit an application, please use the ‘apply’ button above.

   
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