|Funding for:||UK Students, EU Students|
|Placed On:||5th October 2018|
|Closes:||16th November 2018|
PhD Studentship in Quantitative Pharmacology and Neuroscience.
Dr Francesco Tamagnini (Pharmacy), Dr Marcus Tindall (Mathematics & Statistics), Prof Krasimira Tsaneva-Atanasova (University of Exeter, College of Mathematics, Engineering and Physical Sciences).
Neurons work as information relays. They integrate information received from the environment at the subcellular scale, generating an appropriate electrophysiological response. The understanding of electrical processes happening at the plasma membrane level has been clarified by Hodgkin and Huxley, combining experimental recordings to mathematical modelling of equivalent electrical circuits. However, quantitative models describing the effects of cell signalling on the cellular response are lacking.
Adenosine is a neurotransmitter binding both A1 (Gi) and A2 (Gs) receptors. A1 and A2 stimulation results in altered neuronal excitability via K+ permeability changes. In this project, we aim to combine a mathematical model of adenosine receptor signal transduction (Tindall) with the Hodgkin-Huxley model of a neuron (Tsaneva-Atanasova), to generate an in-silico multiscale model of electrophysiological response to chemical stimulation. We will test the predictive capability of the model with whole-neuron patch-clamp recordings (Tamagnini).
The mathematical models formulated during the project will utilise the theory of differential equations (ordinary and partial) solved and analysed both numerically and analytically (e.g. dynamical systems theory, asymptotic methods). The successful candidate will be involved in the design and undertaking of wet laboratory experiments for informing the mathematical models. The final aim of this project is to develop and validate a software capable of predicting changes to an artificial neuron based on its exposure to varying concentrations of a given ligand.
How to apply:
To apply for this studentship please submit an application for a PhD in Pharmacy at www.reading.ac.uk/graduateschool/prospectivestudents/gs-how-to-apply.aspx.
Application Deadline: 16th November 2018
Please note that, where a candidate is successful in being awarded funding, this will be confirmed via a formal studentship award letter; this will be provided separately from any Offer of Admission and will be subject to standard checks for eligibility and other criteria.
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