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PhD Studentship - A New Technological Platform for Personalised Cell Therapy

University of Bath

Qualification Type: PhD
Location: Bath
Funding for: UK Students, EU Students
Funding amount: Home tuition fees, Training Support Fee and stipend (£14,777 p/a, 2018/9 rate)
Hours: Full Time
Placed On: 8th October 2018
Closes: 23rd November 2018

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September/October 2019.

Personalised and advanced therapeutics have the potential to transform the precision of healthcare interventions. For this potential to be realised, however, novel approaches to personalised therapeutic manufacture are required to overcome significant economic and technological challenges. Current manufacturing systems are designed with the ‘one-size-fits-all’ approach, which is not suitable for patient-specific healthcare applications. Our long-term vision is to redefine the manufacture of cell-based therapeutics through the development of a self-regulated on-body micro-manufacturing and processing facility.

With this focus in mind, we propose a highly interdisciplinary PhD project, which, by combining engineering with life science, material chemistry mathematics and physics, will develop an innovative bioelectronic device for cell culturing with integrated sensing capability. We will employ the T lymphocyte cell (T-cell) immunotherapy application as an exemplar. This choice was made given the promising curative potential of T-cells for some of the most aggressive forms of cancer, including Acute Lymphoblastic Leukaemia. Electrochemical monitoring and control of T-cell growth and proliferation in the bioelectronics device will be achieved. Also, the T-cells culturing will be automatized by using a closed-loop control algorithm approach.

In conclusion, this PhD project will lead to the development of an innovative engineering system to ensure robust, reproducible and consistent manufacturing of T-cells, minimise the risk of failure and ultimately facilitate personalised therapeutics.

IMPORTANT: You should apply using the DTP’s online application form:  https://cardiff.onlinesurveys.ac.uk/gw4-biomed-mrc-dtp-student-2019

For more information on the application process visit:

http://www.gw4biomed.ac.uk/doctoral-students/

You do NOT need to apply to the University of Bath at this stage – only those applicants who are successful in obtaining an offer of funding from the DTP will be required to submit an application to study at Bath.

Funding

Studentships cover Home tuition fees, Training Support Fee and stipend (£14,777 p/a, 2018/9 rate) and are open to UK/EU applicants who have been resident in the UK since September 2016.

Start date

30 September 2019

Application link

https://cardiff.onlinesurveys.ac.uk/gw4-biomed-mrc-dtp-student-2019

Relevant subject areas

  • Bioinformatics
  • Biomedical Engineering
  • Biotechnology
  • Cell Biology / Development
  • Electrochemistry
  • Materials Science
  • Applied Mathematics
   
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