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Marie Curie Early Stage Researcher - Therapeutic Antibody Design for the Immune-therapeutic Treatment of Tumours

The University of Edinburgh - College of Science and Engineering

Qualification Type: PhD
Location: Edinburgh
Funding for: UK Students, EU Students
Funding amount: £27,053 to £31,331
Hours: Full Time
Placed On: 9th October 2018
Closes: 22nd October 2018
Reference: 045547

School of Biological Sciences

Applications are invited for one full-time Early Stage Researcher in the laboratory of Dr. Dietmar Zaiss.

One full-time Early Stage Researcher is sought by the laboratory of Dr. Dietmar Zaiss to work towards a PhD as part of the Marie Curie International Training Network, “Tumor-Treg-Targeting”. The research is focused on the design and testing of therapeutic antibodies for the treatment of tumours.

The Zaiss lab studies the underlying processes how immune surveillance can fail leading to the development of tumours, and how antibodies have to be designed to enable the immune system to yet again recognize and eradicate tumours. In this project we will employ the newest developments in antibody design to target the next generation of biologics right towards tumour-residential regulatory T-cells (Tregs) or directly into the tumour micro-environment itself. In this way we will be able to specifically shift the local immune suppressive environment within tumours, while leaving tissue homeostasis in noncancerous tissues unaffected, and thus diminish treatment associated side-effects.

Your research will focus on the design and development of bi-specific antibodies (to be performed at Aduro in Oss, The Netherlands) and the testing of these antibodies in mouse models (to be performed at the University of Edinburgh/UK or at the University of Navara, in Pamplona, Spain).

The position is fixed term for 3 years

Closing Date: 22 October 2018 at 5pm GMT

For further particulars and to apply for this post please click on the 'apply' button below

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