|Funding for:||UK Students, EU Students|
|Funding amount:||£14,777 stipend, Home tuition fees, and Training Support Fee|
|Placed On:||9th October 2018|
|Closes:||23rd November 2018|
Dr Andrew Cookson (University of Bath), Professor Paolo Madeddu (Bristol), Dr Stephen Paisey (Cardiff), Dr Katharine Fraser (Bath)
This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September/October 2019.
Heart attack (myocardial infarction, MI) is the cause of around 37% of heart failure (HF) cases. Current treatment for MI consists of percutaneous coronary intervention, to restore perfusion, and administration of thrombolytic and antiplatelet drugs, to breakdown and prevent clots. However, these are only partially effective; many patients’ hearts still undergo remodelling, leading to HF in the following months. New tools for optimising treatments are therefore needed to improve these outcomes. Numerical models have the potential to predict the interplay between complex biological systems and dynamic, mechanical tissue remodelling.
The aim of this project is to develop a numerical model that links cardiac perfusion with myocardial remodelling and thus address the “Repair” strand of the “Infection, Immunity and Repair” research theme of this Doctoral Training Partnership.
To achieve this scientific aim, we have identified three key objectives:
In order to build and validate this model, various types of experimental data will be used, which is currently being gathered by another PhD student supervised by this team. This data will derive from a mouse model of MI, with contraction assessed by echocardiography. Perfusion will be imaged and quantified using micro-PET-CT, with N-13 ammonia tracer, at points throughout MI and subsequent dilation of the heart. The project involves working at the boundary between the life sciences and physical sciences and, via the supervisory team’s links with the Translational Biomedical Research Centre, the project is targeted to generate knowledge transfer and clinical translation of the research, ultimately leading to improved patient outcomes.
IMPORTANT: You should apply using the DTP’s online application form: https://cardiff.onlinesurveys.ac.uk/gw4-biomed-mrc-dtp-student-2019
For more information on the application process visit:
You do NOT need to apply to the University of Bath at this stage – only those applicants who are successful in obtaining an offer of funding from the DTP will be required to submit an application to study at Bath.
Studentships cover Home tuition fees, Training Support Fee and stipend (£14,777 p/a, 2018/9 rate) and are open to UK/EU applicants who have been resident in the UK since September 2016.
30 September 2019
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