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PhD Studentship: Understanding and evolving enzyme function (WILKINSON_J19DTP2)

University of East Anglia - School of Chemistry

Qualification Type: PhD
Location: Norwich
Funding for: UK Students, EU Students
Funding amount: £14,777 per annum
Hours: Full Time
Placed On: 10th October 2018
Closes: 26th November 2018

Location John Innes Centre, Norwich
Start date: 1/10/2019
Closing date: 26/11/2018
No. of positions available: 1
Hours: Full-time
Contract: Temporary
Supervisor Barrie Wilkinson

Project description

Being ever thrifty, Nature commonly re-purposes (evolves) the functionality of enzymes used in the biosynthesis of valuable natural products for new tasks. A common example involves altering substrate specificity to produce new variants of a rare chemical type. Such enzyme families represent an intriguing opportunity to study protein evolution, and they represent environmentally friendly catalysts for the (bio)chemical synthesis of high value chemicals.

The studentship will investigate this process with the ultimate goal of bioengineering enzymes to carry out new functions, enabling the production of valuable new 'non-natural', natural products for use in medicine, for example as new antibiotics.

The successful candidate will have access to cutting-edge research facilities as well as a stimulating research and training environment. They will be part of an interdisciplinary team and through the project will gain an excellent foundation in protein evolution, molecular microbiology, x-ray crystallography and synthetic biology.

The combination of skills and experience provided by this studentship will make the successful candidate highly employable in academia or industry.

Person Specification UK 2:1 & English Language (6.5 overall, 6 in each section)

Funding notes For funding eligibility guidance, please visit our website: http://biodtp.norwichresearchpark.ac.uk/how-to-apply/funding-and-eligibility. Full Studentships cover a stipend (UKRI rate: £14,777pa – 2018/9), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.  

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.  

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 8th, 9th or 10th January 2019. 

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk 

   
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