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Postdoctoral Research Assistant

University of Dundee - Systems Medicine

Location: Dundee
Salary: £32,236 to £39,609
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 12th October 2018
Closes: 28th October 2018
Job Ref: SMED0446

Duration of employment: 12 Months initially

Appointment will be made at Grade 7, (SP 29-30, £32,236-£33,199)

We wish to recruit an experienced electrophysiologist to join us as a Postdoctoral Research Assistant within the Division of Systems Medicine, Ninewells, Dundee to conduct a programme of work designed to evaluate the utility of novel therapeutics as potential treatments for Fragile X syndrome (FXS).

The research programme is funded by the MRC and is in collaboration with researchers in the Medicines Discovery Institute at the University of Cardiff. The position is initially for one year, with the option for a second year subject to meeting defined project milestones. FXS is the most prevalent, monogenetic cause of autism. There are currently no approved drugs for the treatment of this condition. FXS is associated with impaired cognition, anxiety, aggression, impulsivity and autism. The brains of patients with FXS exhibit abnormal synapse structure. By targeting a mechanism involved in the development and maintenance of synapses, this project aims to identify a drug that can correct the defects in synaptic function associated with this syndrome.

The study will involve making in vitro electrophysiological recordings of FXS hippocampal synaptic transmission and plasticity and to evaluate the influence of novel compounds that target proteins implicated in synaptic dysfunction. The research laboratories are well equipped and staffed by experienced postdoctoral and postgraduate researchers. There will be a close interaction with the Drug Discovery team at the University of Cardiff. You will have the opportunity to participate in internal University of Dundee seminar programmes and will be encouraged to undertake professional development activities available through the University’s Organisation and Professional Development Programme.

Your priorities will include:

  • The delivery of a programme of research to characterise hippocampal synaptic transmission and plasticity in a rodent model of FXS.
  • To determine the effects of novel compounds upon hippocampal synaptic transmission and plasticity in control and FXS models.
  • To prepare progress reports and presentations for project review meetings.

Who we’re looking for:

  • A PhD in neuroscience, or a related subject, with relevant postdoctoral experience.
  • Experience of making in vitro recordings of brain activity, including the use of whole-cell voltage-clamp techniques

The University of Dundee enjoys an international reputation for excellence that attracts top-class students and academics from across the world – with over 140 countries represented in the University community. You will be based at Ninewells Hospital and Medical School, one of Europe’s largest teaching hospitals where the School of Medicine provides outstanding opportunities in medical education and training supported by world class research facilities. The calibre of research at Dundee is high, with 95 per cent of staff working in areas of national or international excellence. Dundee benefits from a developed network of inter-disciplinary researchers collaborating across various Schools across our community. The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall with a full range of disability services, create an enjoyable and inclusive place to work.

For further information about this position please contact Professor Jeremy Lambert at To find out more about the Division of Systems Medicine please visit

Closing date: 28 October 2018

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