|Salary:||£37,904 to £40,994 per annum|
|Placed On:||8th November 2018|
|Closes:||5th December 2018|
Salary: £37,904 to £40,994 per annum
Location: Hammersmith Campus
This is an exciting role in the development of a new fluorescence probe for protective macrophages and hemorrhage.
Apply for this unique post if you want a fascinating project that seamlessly blends chemistry and biology, and want to make a genuine difference to the repertoire of biological and medical optical probes.
You will be responsible for carrying out enzyme assays and fluorescence assays for fluorescent chemical probes of Heme Oxygenase 1, and then discussing results with Dr Boyle and the chemistry team on the same project. This will involve close liaison between the post-holder, Dr Boyle, the recently-appointed chemistry post-doc and Professor Nick Long.
Chemical fluorescence probes for specific biochemical measurements are increasingly popular. This will be the first such probe for heme oxygenase, a major anti-oxidant enzyme.
Vascular Sciences are located in BHF-funded floor in the recently opened Imperial College Translational and Experimental Medicine building, which opened in 2012 as dedicated state-of-the-art laboratories that connect medical science with Hammersmith Hospital.
The Chemistry Department at Imperial College has just moved into state-of-the-art laboratories (Molecular Sciences Research Hub) co-located in the Hammersmith Campus.
This is therefore an ideal opportunity for a chemical biology project such as this postdoctoral research assistantship in fluorescence reporter probes for heme oxygenase 1 (HO-1).
Duties and responsibilities
You will validate fluorescence probes for heme oxygenase 1 at the level of purified enzyme, cell and tissue. The fluorescence probes will have basic fluorescence characteristics measured, and compared with standard heme oxygenase activity assays in enzyme kinetics. You will liaise closely and constructively with the chemists on the project (Ed Walter and Nick Long) and with Joe Boyle. You will carry out data analysis of the probes. This will help build up a validation, and selection of the best probes, in increasingly complex systems. You will understand the probe mechanism and contribute to design discussions. You will spend most of your time on this project. You will also contribute some time more broadly to the wider unit (Vascular Sciences).
The post holder will hold a PhD in Biochemistry, Pharmacology or a closely related discipline or equivalent experience. In addition, knowledge of macrophages, Fluorescence probes and enzymes is essential. In addition, a keen interest in the project is essential as well as the willingness to learn and be flexible.
18 months’ full time, fixed term duration. The start-date of the post is also fixed, early March 2019.
To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED00876.
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