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Research Associate

Imperial College London - National Heart & Lung Institute

Location: London
Salary: £37,904 to £40,994 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th November 2018
Closes: 5th December 2018
Job Ref: MED00876
 

Salary: £37,904 to £40,994 per annum

Location: Hammersmith Campus

Job Summary

This is an exciting role in the development of a new fluorescence probe for protective macrophages and hemorrhage.

Apply for this unique post if you want a fascinating project that seamlessly blends chemistry and biology, and want to make a genuine difference to the repertoire of biological and medical optical probes.

You will be responsible for carrying out enzyme assays and fluorescence assays for fluorescent chemical probes of Heme Oxygenase 1, and then discussing results with Dr Boyle and the chemistry team on the same project. This will involve close liaison between the post-holder, Dr Boyle, the recently-appointed chemistry post-doc and Professor Nick Long.

Chemical fluorescence probes for specific biochemical measurements are increasingly popular. This will be the first such probe for heme oxygenase, a major anti-oxidant enzyme.

Vascular Sciences are located in BHF-funded floor in the recently opened Imperial College Translational and Experimental Medicine building, which opened in 2012 as dedicated state-of-the-art laboratories that connect medical science with Hammersmith Hospital.

The Chemistry Department at Imperial College has just moved into state-of-the-art laboratories (Molecular Sciences Research Hub) co-located in the Hammersmith Campus.

This is therefore an ideal opportunity for a chemical biology project such as this postdoctoral research assistantship in fluorescence reporter probes for heme oxygenase 1 (HO-1).

Duties and responsibilities

You will validate fluorescence probes for heme oxygenase 1 at the level of purified enzyme, cell and tissue. The fluorescence probes will have basic fluorescence characteristics measured, and compared with standard heme oxygenase activity assays in enzyme kinetics. You will liaise closely and constructively with the chemists on the project (Ed Walter and Nick Long) and with Joe Boyle. You will carry out data analysis of the probes. This will help build up a validation, and selection of the best probes, in increasingly complex systems. You will understand the probe mechanism and contribute to design discussions. You will spend most of your time on this project. You will also contribute some time more broadly to the wider unit (Vascular Sciences).

Essential requirements

The post holder will hold a PhD in Biochemistry, Pharmacology or a closely related discipline or equivalent experience. In addition, knowledge of macrophages, Fluorescence probes and enzymes is essential.  In addition, a keen interest in the project is essential as well as the willingness to learn and be flexible.

Further Information

18 months’ full time, fixed term duration. The start-date of the post is also fixed, early March 2019.

Should you require any further details on the role please contact: Joseph (Joe) Boyle – joseph.boyle@imperial.ac.uk / -            https://www.imperial.ac.uk/people/joseph.boyle

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED00876.

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

   
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