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Postdoctoral Fellow - Integrative Structural Studies of Peroxisomal Translocon Complexes

European Molecular Biology Laboratory (EMBL)

Location: Hamburg - Germany
Salary: Competitive
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 6th December 2018
Closes: 13th January 2019
Job Ref: HH00159

Organisation data: Wilmanns Group

About the team/job

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes of medical relevance. Our main research interest is on structures of large protein translocation systems and structural dynamics of giant muscle proteins. We additionally collaborate on specific research projects with several clinical groups with interests in tuberculosis, cancer and hereditary diseases. Most of our projects require integrative structural biology methods including X-ray crystallography, electron microscopy and complementary biophysical and biochemical approaches. The group shares expertise and research infrastructures with other EMBL research groups in Hamburg.

Your role

The peroxisomal translocon consists of a dynamic multi protein component complex and allows the transport of large, folded and functional target proteins. Building on our previous record in determining structure/function relationships of protein components of the peroxisomal translocon, we are aiming to determine structure and function of both the entire peroxisomal translocon as well as sub-complexes (substrate recognition/release, receptor docking) by combining integrated structural biology approaches. These include X-ray crystallography, electron microscopy, biophysical and computational approaches. The fellowship is supported by a multidisciplinary research consortium, which opens opportunities for collaboration, exchange, and participation at international meetings. 

You have

Applicants should have a PhD in a relevant field, proven record of scientific accomplishments, international experience, scientific ambition and excellent communication skills, and previously demonstrated expertise in structural biology and biophysical approaches including sample preparation (molecular biology, heterologous expression in eukaryotic host and/or yeast, protein purification). 

You might also have

Additional expertise in biochemistry (in vitro and cell-based assays) and cell biology (including imaging) would be advantageous.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. Scientists at the EMBL Hamburg Unit benefit from cutting-edge technology to accommodate their research, with on-site synchrotron radiation beamlines operated by EMBL and opportunities for collaboration with colleagues from all six EMBL units.

What else do I need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Informal inquiries should be sent to: wilmanns@embl-hamburg.de.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review. 

To learn more about working & living in Germany, please visit: www.jobs.ac.uk/germany

   
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