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Targeted Protein Degradation Using Small Molecules

University of Sussex - Biochemistry

Qualification Type: PhD
Location: Falmer
Funding for: UK Students, EU Students
Funding amount: £14,777 stipend at standard Research Council rates
Hours: Full Time
Placed On: 10th December 2018
Closes: 4th February 2019

A Ph.D. studentship (48 months) is available from October 2019 under the joint supervision of Profs John Spencer and Georgios Giamas, Chemistry and Biochemistry Departments, School of Life Sciences.

Deadline: 4 February 2019.

Recent work from the Giamas group has concentrated on the discovery and mechanism of action of Lemur Tyrosine Kinase 3 (LMTK3). The latter is implicated in resistance to endocrine cancer therapies including tamoxifen, by phosphorylation of the ERa protein (http://www.sussex.ac.uk/lifesci/giamaslab/). A recent, unpublished, collaboration with the Spencer group (http://www.sussex.ac.uk/lifesci/spencerlab/) has led to the discovery of selective, nM potent LMTK3 inhibitors. This iCASE project, in partnership with GlaxoSmithKline (GSK), funded by GSK and EPSRC, will be based at Sussex and involve a 3-month placement at GSK, Stevenage. It will look to produce PROTACs (proteolysis targeting chimeras) to selectively target LMTK3 and destroy it via the proteasome. Further studies will explore novel modalities of inducing protein degradation.

Please submit a formal application using our online application system at http://www.sussex.ac.uk/study/phd/apply, including a CV, degree transcripts and certificates, statement of interest and names of two academic referees.

On the application system, use Programme of Study – PhD Biochemistry.

Please make sure you include the project title and Supervisor’s name with your statement of interest on the application form.

This is open to UK or EU nationals who have been resident in the UK for the 3 years prior to taking up the scholarship.  The stipend is at standard Research Council rates, currently £14,777 per annum.

Ideal candidates will have a strong background in synthetic organic/medicinal chemistry with additional experience of cellular and structural biology. Eligible applicants will have recently received an MSc and/or a First or high 2:1 BSc in a relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.

Contact Anna Izykowska for application enquiries (a.izykowska@sussex.ac.uk) and j.spencer@sussex.ac.uk; G.Giamas@sussex.ac.uk for enquiries about the project.

   
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