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Postdoctoral Fellow - Nanobody Technologies for Structural Biology

European Molecular Biology Laboratory (EMBL)

Location: Hamburg - Germany
Salary: Competitive salary
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th January 2019
Closes: 10th February 2019
Job Ref: HH00164

About the team/job

We are seeking for a highly motivated molecular biologist with protein biochemistry expertise to develop the use of single domain antibodies as a platform technology for structural and functional studies at the EMBL Hamburg unit. The research portfolio of the Hamburg Unit mainly focuses on research of structures of large protein complexes and machineries by diverse structural biology approaches including X-ray crsytallography and cryo-electron miccroscopy. The successful candidate will work in a collaborative environment together with structural and computational biologists. You will be affiliated with the research group of Christian Löw. The Löw laboratory is specialized in structural biology of integral membrane proteins. The team uses innovative approaches to study the structure and dynamics of nutrient uptake systems.

Your role

Your task will be to establish an in vitro/in vivo nanobody selection approach to identify binders against selected membrane proteins, which then will be used as tools for structural (X-ray or Cryo-EM) and functional studies (e.g. Imaging, transport assays). The work aims at biological discoveries comprising both methodological and applied aspects. Your expertise will be accessible to all interested research groups and teams from the EMBL Hamburg Unit.

You have

  • A Ph.D. degree in biochemistry, biophysics or structural biology (or a related field)
  • Strong experience in molecular biology and protein biochemistry with a demonstrated record of accomplishments
  • Ability to plan and pursue a research project independently and in a team
  • Willingness to learn new skills as projects require
  • Good communication, interpersonal and English language skills

You might also have

  • Experience in phage display or ribosome display technologies
  • Experience in structural biology (X-ray, Cryo-EM) of integral membrane proteins or larger protein complexes
  • Experimental expertise in the field of membrane transporters
  • Familiarity with eukaryotic expression systems

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. Scientists at the EMBL Hamburg Unit benefit from cutting-edge technology to accommodate their research, with on-site synchrotron radiation beamlines operated by EMBL and opportunities for collaboration with colleagues from all six EMBL units.

What else do I need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

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