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Research Associate in Mechanistic Investigations of Membrane Proteins

Imperial College London - EPR Spectroscopy & Bioinorganic Chemistry Group, Department of Chemistry

Location: London
Salary: £37,904 to £45,547 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd January 2019
Closes: 21st February 2019
Job Ref: NAT00361

White City Campus

Fixed Term: Up to 3 years from March 2019

Proteins with redox functionality are ubiquitous in nature and fulfil a wide range of roles ranging from the regulated transfer of electrons to catalysis of essential reactions in e.g. respiration and photosynthesis. Numerous methods have been developed to study these proteins and yet many fundamental questions cannot be answered due to missing tools. We are looking to appoint a Research Associate who will pioneer a novel way to investigate the mechanism of redox-active catalysts, particularly large metalloenzymes, in a highly interdisciplinary project that requires teamwork. The successful candidate will join the group of Dr Maxie Roessler in the Department of Chemistry as part of a Leverhulme Trust funded project entitled “Film-electrochemical EPR: a new method to investigate redox-based catalysis”. The project will be in collaboration with Professor Erwin Reisner (University of Cambridge) for the preparation of metal-oxide materials and benefit from on-going work with Professor Judy Hirst (Medical Research Council, Cambridge) on respiratory complex I. For background information see JACS 2017, 139, 16319; Chem. Soc. Rev. 2018, 47, 2534; Acc. Chem. Res. 2016, 49, 884.

The post holder will be responsible for designing and realising the spectroelectrochemical set-up, preparing and characterising proteins (including through EPR spectroscopy), designing and realising the attachment of the proteins to working electrode materials.  She or he will be expected to plan and carry out research, to write up results for publication and oral presentations, to liaise with collaborators, and to assist in the maintenance of lab facilities and the administration of the research team and to support research students.

The following are essential requirements for the role:

  • To hold a PhD, or equivalent level of professional qualifications and experience, in Chemistry, Biochemistry, Material Science or a related discipline
  • BSc and Master (or equivalent) degree in Chemistry, Biochemistry, Materials Science or related field
  • Experience in EPR spectroscopy and/or electrochemistry
  • Experience in protein preparation and/or characterisation
  • Demonstrated capability to advance methodology
  • Excellent verbal communication skills and the ability to deal with a wide range of people, along with team working skills
  • Excellent written communication skills and the ability to write clearly and succinctly for publication
  • Ability to plan and conduct research independently

The following are desirable requirements for the role:

  • Experience with membrane proteins
  • Experience with Protein Film Electrochemistry
  • Experience with functionalising materials
  • Experience with designing and constructing EPR resonators or related equipment  

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £33,380 - £35,061 per annum

For additional information please contact Ms Lisa Benbow, Administrator,

Closing Date: 21st February 2019 (midnight)

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