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PhD Studentship DNP-enhanced NMR Studies of Cellular Membrane Disruption Induced by Abeta40 Peptides

University of Nottingham - Physics & Astronomy

Qualification Type: PhD
Location: Nottingham
Funding for: UK Students, EU Students
Funding amount: Stipend covering PhD tuition fees & tax-free living allowance
Hours: Full Time
Placed On: 21st February 2019
Closes: 19th May 2019
Reference: SCI1867

Location: University Park

Supervisor: Dr Alexey Potapov

We are looking for a motivated PhD candidate interested in biophysical applications of magnetic resonance spectroscopy. This position is suitable for students with background in Physics, Chemistry or other related fields.

Aggregates of amyloid-beta peptides have been proposed to play role in causing Alzheimer's disease, however, their mechanism of action is not clearly understood. In this project, carried out in collaboration with SUNY Binghamton (USA), we focus on the process of cell membrane disruption by amyloid-beta and study its details using advanced nuclear magnetic resonance (NMR) techniques. One of such techniques is the dynamic nuclear polarization (DNP) allowing the NMR signals to be increased by a large factor. University of Nottingham is hosting a modern DNP-enhanced solid-state NMR Facility (unique in the UK) funded by a grant of £2.5 M from EPSRC. 

The PhD studentship is available immediately, and is fully funded for 3.5 years via a stipend covering PhD tuition fees (at the Home/EU rate) and a tax-free living allowance. 

The Sir Peter Mansfield Imaging Centre, which is part of the School of Physics and Astronomy of the University of Nottingham, is well equipped and conducts a very active research program in many aspects of modern magnetic resonance (http://www.nottingham.ac.uk/magres/index.aspx). For more details please contact Dr Alexey Potapov (alexey.potapov@nottingham.ac.uk)

   
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