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Research Assistant

King's College London - Division of Cancer Studies / Dept of Haematological Medicine

Location: London
Salary: £31,883 to £36,422 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd March 2019
Closes: 21st April 2019
Job Ref: R5/0640/19-DB

The salary will be paid at Grade 5, £31,883 to £36,422 per annum, inclusive of £3,223 per annum London Allowance.

Idiopathic severe aplastic anaemia (SAA) is a rare, chronic immune mediated bone marrow failure disorder. Treatment with immunosuppressive therapy (IST) induces response in 65%of patients. For refractory SAA, response to a novel agent, eltrombopag, occurs in 40% of patients. 

The project is to serially characterize the evolving clonal architecture through identification of somatic mutations in blood and bone marrow samples from SAA patients treated with eltrombopag in the ‘RACE’ trial. We will utilize a targeted gene panel approach in the first instance to comprehensively screen and monitor all patient bone marrow or blood samples longitudinally through the drug trial for acquired clonal mutations Additional genomic techniques will also be employed to follow-up and expand on these initial findings as appropriate. We will relate this serial mutational data with later risk of transformation to MDS/AML, and hence develop a novel, pathogenetic molecular signature/biomarker that provides earlier and more accurate prediction of risk of MDS/AML

Contract Type: This post will be Fixed Term Contract for 14 months. 

Contract Term: This is a full time post (35 hours per week) 

Selection process: The selection process will include an interview 

Contact: Dr Alex Smith 

Application details: To apply, please register with the King’s College London application portal and complete your application online.

Additional application details: (Optional)

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The successful candidate will have a good first degree (2:1 or higher) or equivalent in a suitable biological science subject, have post graduate (post 1st degree) full-time laboratory experience and well developed skills in modern molecular biology techniques, including PCR and sequencing-based methodologies. Furthermore, it is mandatory that the candidate has extensive professional working  experience with next generation sequencing methodologies and appropriate library preparation techniques. Skills in related analysis pipelines would also be desirable. The candidate also needs good experience in cell fractionation techniques and handling primary human tissues, as well as experience in cancer molecular biology. 

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