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Research Fellow

University of Birmingham - College of Medical and Dental and Sciences Institute of Immunology and Immunotherapy

Location: Birmingham
Salary: £30,395 to £39,609
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd March 2019
Closes: 29th April 2019
Job Ref: 51761

Fixed Term – 3 Years

Full time starting salary is normally in the range £30,395 to £39,609. With potential progression once in post to £42,036 a year.

The University is committed to safeguarding and we promote safe recruitment practice, therefore all associated pre-employment checks will be undertaken before any appointment is confirmed. 

We are seeking a highly motivated individual for a postdoctoral position to work within a CRUK funded research programme that seeks to understand the mechanisms of immune evasion and immune suppression in pancreatic ductal carcinoma (PDA). This is a Programme award from Cancer Research UK. 

The post holder will have specific responsibility for investigating the biology of the tumour infiltrate in patients with PDA, with a focus on lymphoid cells. 

With a PhD in a relevant subject area and laboratory experience in tumour immunobiology, you are expected to have practical experience in culturing primary cells, immunophenotyping, molecular cloning and T-cell based functional assays. Proven experience is required in the isolation and enrichment of immune cell subsets and tumour-associated stroma from fresh tumour tissue. Knowledge of T cell cloning including the discovery of novel HLA-restricted tumour specific peptide epitopes would be an advantage. 

Techniques involved

  • Isolation, enrichment and culturing of immune cell subsets and tumour associated stroma from fresh tumour specimens.
  • Phenotypic and functional characterisation of the tumour infiltrating lymphocytic and myeloid cells from fresh tumour specimens
  • Flow cytometry and cell sorting
  • T cell cloning including the discovery of novel HLA restricted tumour specific peptide epitopes.
  • PCR techniques including RT-qPCR and endpoint PCR.
  • Molecular cloning including transfection/transduction of cell lines and primary immune cells 

Main duties:

Develop research objectives and proposals for own or joint research, with assistance of a mentor if required

Contribute to writing bids for research funding

Analyse and interpret data

Apply knowledge in a way which develops new intellectual understanding

Disseminate research findings for publication, research seminars etc 

Person specification 

  • First degree in life sciences and a higher degree relevant to the study of immunology (in particular tumour immunology)
  • An in depth knowledge of tumour immunology including modern concepts of immune regulation and checkpoint blockade
  • Good knowledge of T cell mediated immunity.
  • Practical experience in western blot techniques.
  • Practical experience in mulit-parameter flow cytometry for phenotypic and functional analysis of the tumour-specific T cells.
  • Proven track record in molecular cloning including transfection and transduction of primary cells and cell lines 

Closing date: 29 April 2019  

To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from www.hr.bham.ac.uk 

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