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Research Associate

Cardiff University - Medicines Discovery Institute, Cardiff School of Biosciences

Location: Cardiff
Salary: £33,199 to £39,609 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 25th March 2019
Closes: 25th April 2019
Job Ref: 8393BR

The Medicines Discovery Institute (MDI) at Cardiff University are looking for a driven Medicinal Chemist to support their α2/α3-GABAAR project, as a Research Associate. This exciting project aims to use a streamlined preclinical and clinical development path in to identify a first-in-class molecule for the treatment of anxiety disorders. The successful candidate will play an important role in the success of the project, through designing efficient synthetic routes and undertaking synthesis and characterisation of target molecules. Applications are therefore welcomed from individuals who have previously made a successful contribution to Chemistry research projects, with experience in purification and synthesis of molecules.
The post will be based at Cardiff University’s Main Building, where the role-holder will be part of a welcoming and collaborative multi-disciplinary drug discovery team.  For informal inquiries, please contact

Project Summary:
By removing the sedation side-effect of other treatments, a selective α2/α3-subtype GABAAR positive allosteric modulator is an ideal target for the treatment of General Anxiety Disorder. Recent molecular genetic studies have established that positive allosteric modulator which is selective for α2/α3-containing GABAARs but is devoid of effects at α1 GABAARs should be a non-sedating anxiolytic. Several α2/α3-GABAAR positive allosteric modulators have been described and they reproducibly demonstrate a non-sedating anxiolytic activity in previous experiments.

Please see additional information to learn more about the MDI

This post is full-time (35 hours) fixed-term and available from 1st July 2019 until 31 December 2020. However, in supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

Salary: £33,199 - £39,609 per annum (Grade 6)

Important note: Interviews will be held week commencing Monday 6th May 2019.

Closing date: Thursday, 25 April 2019

Please be aware that Cardiff University reserves the right to close this vacancy subject to 24 hours’ notice, should sufficient applications be received.

In Higher Education, female and BME (black and minority ethnic) staff are underrepresented across a number of career paths. Applications are therefore particularly welcome from applicants who identify as female and/or BME. We also welcome applications from members of the LGBT+ Community. Cardiff University is also committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world

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