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Research Fellow (Sequencing Molecular Biology)

University of Birmingham - School of Biosciences

Location: Birmingham
Salary: £30,395 to £39,609
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 17th April 2019
Closes: 31st May 2019
Job Ref: 81149

Full Time

FTC up to June 2022

Grade 7

Full time starting salary is normally in the range £30,395 to £39,609. With potential progression once in post to £42,036 a year. 

We seek to recruit a full-time postdoctoral-level Research Fellow in Sequencing Molecular Biology to work in the laboratory of Professor Nick Loman on an exciting Wellcome Trust Technology Development Award to develop new methods for long read sequencing to enable – for the first time – complete whole genome assemblies of complex genomes.

Working with an experienced team and in close collaboration with Professor Matt Loose’s laboratory at the University of Nottingham we are developing an collaborative, worldwide, open approach to developing new molecular biology methods for use on long-read sequencing platforms (e.g. Oxford Nanopore, Pacific Biosciences, 10X Genomics, BioNano, etc.). Your work will be part of our newly formed Long Read Club (longreadclub.org). The grant aims to enable end-to-end chromosomal-level assemblies (including telomeres and centromeres) routinely at scale for genome sequencing projects.

The Research Fellow in Sequencing Molecular Biology will focus primarily on developing new methods for long fragment DNA extraction and molecular biology methods for sequencing library construction in order to reliably generate multi-megabase length sequencing reads, going “beyond kits”. This will include development and refinement of existing transposase-based protocols (e.g. our existing ultra—long read protocol: https://www.protocols.io/view/ultra-long-read-sequencing-protocol-for-rad004-mrxc57n), new methods to protect high molecular weight DNA during library preparation and rediscovery and testing of forgotten extraction and molecular biology techniques. You will also take part-responsibility for Long Read Club protocols and online meetings to widely disseminate the outputs of the grant and to build a community of users interested in these methods.

Skills and Experience 

Applicants should hold a PhD in biology, molecular biology, genomics, sequencing or chemistry, with some experience in the development of molecular biology methods and protocols or equivalent qualifications.

  • High level analytical capability
  • Ability to communicate complex information clearly
  • Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
  • Ability to assess resource requirements and use resources effectively
  • Understanding of and ability to contribute to broader management/administration processes
  • Experience writing molecular biology protocols for others to follow
  • Knowledge of DNA molecular biology and extraction techniques
  • Some experience with single molecule sequencing techniques such as Oxford Nanopore and Pacific Biosicenecs 

Closing date: 31.05.2019                   

To download the details and submit an electronic application online please click on the Apply Online button below; please quote Job Reference in all enquiries. Alternatively information can be obtained from 0121 415 9000 or visit www.birmingham.ac.uk/jobs

   
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