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Postdoctoral Training Fellow

The Francis Crick Institute

Location: London
Salary: Competitive with benefits, subject to skills and experience.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd May 2019
Closes: 23rd June 2019
Job Ref: 009566

The Francis Crick Institute recruitment system will be unavailable from Monday 10th June to Sunday 16th June. Please be aware that you will be able to submit your application through the institute’s website for this vacancy from Monday 17th June.

Contract: Fixed-term, 4 years

Short summary

We seek a talented and motivated postdoc in computational biology to join the Cancer Genomics laboratory of Peter Van Loo. The post holder will perform large-scale genomics analyses of sarcomas in the context of Genomics England’s 100,000 Genomes project, characterizing the landscape of driver mutations and mutational processes across sarcoma entities, and studying the evolutionary history of sarcomas. 

Project scope 

Sarcomas are tumours of mesenchymal origin, encompassing approximately 1% of adult cancers and 15% of childhood cancers. They represent a collection of individually rare cancer types that are often understudied. Through the 100,000 Genomes Project, the UK sarcoma community has collected whole-genome sequences of >1,700 cancer samples from >1,300 sarcoma patients. This now allows us an exciting and unprecedented view into the genomics of these cancers. As part of the Sarcoma GeCIP (Genomics England Clinical Interpretation Partnership), the Cancer Genomics group has taken the lead in the somatic genomics analyses of these data. 

This is a highly collaborative project, in which the successful candidate will lead analyses into the drivers, mutational processes and evolution of these sarcomas. The candidate will: 

  • Collaborate closely with a sarcoma GeCIP core bioinformatician to set up and run pipelines for genomics analyses (alignment, SNV calling, indel calling, SV calling and copy number calling).
  • Perform analyses of recurrent SNV, indel and SV drivers across sarcoma entities.
  • Perform studies of copy number complexity, chromothripsis, and other mutational processes.
  • Study intra-tumour heterogeneity using single-sample and multi-sample (approx. ¼ of the cases) analyses, potentially supplemented with single-cell analyses.
  • Perform timing analysis of mutations, copy number changes and punctuated evolutionary processes, and infer timelines of sarcoma evolution.
  • Work closely with sarcoma GeCIP leadership (steering committee: Adrienne Flanagan (main sarcoma GeCIP lead), Peter Van Loo, Gareth Bond, Stephan Beck) and other GeCIP members to facilitate complementary and downstream analyses.

About us 

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • The closing date for applications is 23 June 2019 at 23:30.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 
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