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Advanced Research Assistant - Vidal-Puig Faculty

Wellcome Sanger Institute

Fixed term contract

We are seeking an enthusiastic, motivated Advanced Research Assistant to join an exciting project funded by the European Research Council.

The project focuses on thermogenesis and brown adipose tissue (BAT) related strategies to treat obesity and metabolic complications. This objective will be fulfilled by using a human pluripotent stem cell (hPSCs) based approach.

The specific objectives of the research are:

  1. a) To identify and validate molecular mechanisms involved in human brown adipose tissue development and activation;
  2. b) To investigate the molecular mechanisms involved in human brite cells recruitment and ultimately
  3. c) To identify new compounds of therapeutic value able to activate or recruit human brown adipose tissue/brite cells.

Research strategy: Involves the use human state of the art PSCs differentiated to BAT/WAT precursors and adipocytes.These cellular models will be coupled with transcriptomic analysis (bulk RNAseq and single nuceli RNAseq) of human BAT/WAT precursors and mature/activated adipocytes. This strategy will identify new candidate genes/molecules involved in the differentiation and activation of these cells. Other more targeted –omics analysis (e.g. lipidomic analysis/proteomics) will be integrated using bioinformatics approaches. The role of the new players will be assessed specifically by generating loss and/or gain of function hPSC cell lines and assessing their capacity to form functional BAT/WAT and WAT browning. Finally, the most successful candidates will be validated in vivo using a transplantation model. In summary, this project will provide multidisciplinary training in a very competitive and exciting area.

Essential Skills

  • Science degree in biological sciences or equivalent or extensive, proven practical experience
  • Relevant working laboratory experience
  • Practical experience in mammalian cell culture (desirable) including human ES or iPS cells (essential)
  • Understanding and practical experience in imaging techniques such as immunofluorescence and confocal microscopy
  • Understanding and practical experience flow and sorting techniques
  • Ability to test and implement new approaches and techniques including troubleshooting
  • Capable of working to a schedule and delivery of a variety of challenging projects simultaneously within agreed deadlines
  • Ability to work both as part of a team and also independently once appropriate training and guidance have been provided.
  • Excellent laboratory practice
  • Good communication skills to allow accurate information to be exchanged

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

This position is funded to 31st December 2020, however applicants should note that this may be extended to 30th June 2021 subject to an extension of funding.

Please include a covering letter and CV with your application. Closing date for applications: 17th July 2019

Location: Cambridge, Hinxton
Salary: £26,960 to £32,622 (dependent on experience) plus excellent benefits
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 17th June 2019
Closes: 17th July 2019
Job Ref: 83524
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