Fixed term contract
We are seeking an enthusiastic, motivated Advanced Research Assistant to join an exciting project funded by the European Research Council.
The project focuses on thermogenesis and brown adipose tissue (BAT) related strategies to treat obesity and metabolic complications. This objective will be fulfilled by using a human pluripotent stem cell (hPSCs) based approach.
The specific objectives of the research are:
Research strategy: Involves the use human state of the art PSCs differentiated to BAT/WAT precursors and adipocytes.These cellular models will be coupled with transcriptomic analysis (bulk RNAseq and single nuceli RNAseq) of human BAT/WAT precursors and mature/activated adipocytes. This strategy will identify new candidate genes/molecules involved in the differentiation and activation of these cells. Other more targeted –omics analysis (e.g. lipidomic analysis/proteomics) will be integrated using bioinformatics approaches. The role of the new players will be assessed specifically by generating loss and/or gain of function hPSC cell lines and assessing their capacity to form functional BAT/WAT and WAT browning. Finally, the most successful candidates will be validated in vivo using a transplantation model. In summary, this project will provide multidisciplinary training in a very competitive and exciting area.
The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.
Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
This position is funded to 31st December 2020, however applicants should note that this may be extended to 30th June 2021 subject to an extension of funding.
Please include a covering letter and CV with your application. Closing date for applications: 17th July 2019
|Salary:||£26,960 to £32,622 (dependent on experience) plus excellent benefits|
|Placed On:||17th June 2019|
|Closes:||17th July 2019|
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